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GenomicsTGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
We examined tumours from a large cohort of patients with metastatic urothelial bladder cancer (mUC) treated with an anti–PD-L1 agent (atezolizumab) and identified major determinants of clinical response and immune escape. Whole transcriptome profiles were generated for 368 patients using TruSeq RNA ...
EGAS00001002556 | EGA
TranscriptomicsGlobal Target mRNA Specification and Regulation by RNA-Binding Protein ZFP36/Tristetraprolin/TTP [PAR-CLIP]
Tristetraprolin/ZFP36/TTP and ELAVL1/HuR are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich sequences but have antagonistic roles. While ELAVL1 binding has been profiled in several studies, the precise in vivo binding specificity of ZFP36 has not been investigated o...
ORGANISM(S): Homo sapiens 
2013-12-24 | E-GEOD-53184 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours.
Purpose: Human papilloma virus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than HPV(-) negative cancer. This may be due, in part, to the higher number of tumour infiltrating lymphocytes (TIL) in HPV(+) tumours. We used RNAseq to evaluate whether these differ...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72536 | biostudies-arrayexpress
UnknownA dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells.
Not available
S-EPMC10541883 | biostudies-literature
TranscriptomicsT helper lymphocyte- and monocyte-specific type I interferon (IFN) signatures in autoimmunity and viral infection.
This study demonstrates quantitative and qualitative differences between type I IFN signatures in autoimmunity and viral infection using purified CD4pos T cells and CD16pos- and CD16neg-monocyte subsets. We were able to discriminate between cell-specific viral response signatures and the pathogenica...
ORGANISM(S): Homo sapiens 
2014-01-06 | E-GEOD-51997 | biostudies-arrayexpress
TranscriptomicsSugar turns benefit of cholesterol into immune evasion in Helicobacter pylori infected C57BL/6 mice
Following the initial demonstration of Helicobacter pyloriâ??s pathogenic potential, evidence has been accumulated that H. pylori is the leading cause of gastric ulcers, carcinoma and lymphoma3. Cholesterol is a physiological constituent of membranes critical for their biophysical properties, but is...
ORGANISM(S): Mus musculus 
2010-06-30 | E-GEOD-3878 | biostudies-arrayexpress
UnknownA method for large-scale identification of protein arginine methylation.
Not available
S-EPMC3494207 | biostudies-literature
OtherA Method for Large-scale Identification of Protein Arginine Methylation
PASSEL ID: PASS00081. Original data file: B100910_042.mzXML. Data published as part of Mol Cell Proteomics. 2012 11:1489-99 . From the Abstract: {{i}} ... Here we show that most tryptic peptides containing methylated arginine(s) are highly basic and hydrophilic. Consequently, they could be consider...
ORGANISM(S): Human 
GPM11210008866 | GPMDB
UnknownMutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo.
Not available
S-EPMC7190032 | biostudies-literature
ProteomicsIn-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome.
Molecular communication between cancer cells and its stromal microenvironment is a key factor for cancer progression. Alongside classic secretory pathways, it has recently been proposed that small membranous vesicles are alternative mediators of intercellular communication. Exosomes carry an effecto...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080278 | MassIVE
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