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GenomicsWhole Exome Sequencing for Familial Intracranial Aneurysm (FIA I-II) Study

The goal of this study is to identify the genes underlying the risk of intracranial aneurysm (IA). The FIA Study initially recruited families appropriate for linkage analysis. Therefore, the recruitment focus was not only on probands with a family history of IA but also required that biological s...

phs000636.v1.p1 | EGA
ProteomicsNucleo-cytoplasmic distribution of SAP18 reveals its dual function in splicing and thermotolerance in Arabidopsis
The dynamic shuttling of proteins between the nucleus and cytoplasm orchestrates vital functions in eukaryotes. Here, we unveil multifaceted functions of Arabidopsis Sin3-associated protein 18 kDa (SAP18) in regulating development and stress tolerance. As a crucial component of the Apoptosis- and Sp...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-11-04 | PXD050985 | Pride
Asap complex  plant development  alternative splicing  heat stress  arabidopsis thaliana  biomolecular condensates  leaf development  thermoprotection  stress granules  shuttling proteins. 
GenomicsCIDR: Genome Wide Association Study in Familial Parkinson Disease (PD)

This proposal brings together the two largest NIH funded genetic studies focused on the identification of novel genes that influence the risk of PD. These two studies, PROGENI (PI: Tatiana Foroud; R01NS037167) and GenePD (PI: Richard Myers; R01NS036711) have been evaluating and recruiti...

phs000126.v1.p1 | EGA
TranscriptomicsTranscription profiling of mouse models of sepsis cecal ligation and puncture and tracheal instillation of P. aeruginosa reveals bcl-2 overexpression modulates transcription responses in vivo
Background: We hypothesized that spleen microarray gene expression profiles analyzed with contemporary pathway analysis software would provide molecular pathways of interest and target genes that might help explain the affect of bcl-2 on improving survival during sepsis. Methods: Two mouse models of...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5811 | biostudies-arrayexpress
GenomicsThe Familial Intracranial Aneurysm Linkage Study (FIA)

Our long-term objective is to identify susceptibility genes that are related to the formation of intracranial aneurysms (IA). Rupture of IAs occurs in 16,000 to 17,000 persons in the U.S. annually and nearly half of affected persons are dead within the first 30 days. An additional 6,000 to 7,000 ...

phs000293.v1.p1 | EGA
UnknownAge- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.
Not available
S-EPMC5019754 | biostudies-literature
TranscriptomicsTranscription profiling of human lymphocyte response to E. coli to identify any transcriptional component to the protection in vitro bacterially induced PBMC apoptosis
Sepsis induces lymphocyte apoptosis which can be prevented by over-expression of anti-apoptotic Bcl-2 family members. The anti-apoptotic activity of Bcl-2 family members is localized in the BH4 domain. The therapeutic peptide, TAT-BH4, was found to prevent sepsis-induced lymphocyte apoptosis in vi...
ORGANISM(S): Homo sapiens 
2006-02-07 | E-MEXP-555 | biostudies-arrayexpress
UnknownEfficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial.
Not available
S-EPMC5891132 | biostudies-literature
UnknownMetabolic buffering restricts phenotype switching in melanoma
Not available
S-SCDT-10_1038-S44318-026-00857-2 | biostudies-other
TranscriptomicsCell-density resolved comparative analysis of D. shibae wild-type vs. delta-luxI1 overexpressing luxI1 in trans
D. shibae delta-luxI1 overexpressing the luxI1 gene in trans was compared to the wild-type in order to identify quorum sensing controlled traits in this organism. Samples were taken at different optical densities in the exponential phase and in the stationary phase. Samples from Dinoroseobacter shib...
ORGANISM(S): Dinoroseobacter shibae DFL 12 
2012-11-03 | E-GEOD-42012 | biostudies-arrayexpress
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