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From a tumoral line IGR-Heu; resulting from a biopsy of the primitive tumour of a patient reached of a bronchial cancer not with small cells (NSCLC); we established; by successive co-cultures of this line with the autologous CTL (clone T H161); a resistant line to the cytotoxic lysis induced by H16...
ORGANISM(S): Homo sapiens 
T1 and G1 are the two melanoma cell lines, established from primary tumor (T1) and lymph node metastases (G1) of a 77 years old male patient. While G1 cells were resistant to TRAIL (TNF-related apoptosis-inducing ligand) mediated cell death, T1 cells exhibited a high dose- and time-dependent sensiti...
ORGANISM(S): Homo sapiens 
A 244 K genome-wide array based comparative genomic hybridization study was carried out in a familial translocation t(2;6)(p25;p21) balanced in the mother (SDM) and unbalanced in her daughter (SD). In the past, this translocation has allowed to localize the HLA multigene cluster to chromosome 6. Wit...
ORGANISM(S): Homo sapiens 
Hypoxia-mediated inhibition of specific tumour cell lysis
ORGANISM(S): Homo sapiens 
The aim of the present study was to investigate the potential role of HIF-2a in regulating RCC susceptibility to natural killer (NK) cell-mediated killing. We demonstrated that the RCC cell line 786-O with mutated VHL was resistant to NK-mediated lysis as compared to the VHL corrected cell line (WT7...
ORGANISM(S): Homo sapiens 
Although fine needle aspiration (FNA) cytology is helpful in determining whether thyroid nodules are benign or malignant, this distinction remains challenging in follicular neoplasms. Identification of genomic alterations in cytological specimens that distinguish between benign and malignant follicu...
ORGANISM(S): Homo sapiens 
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