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GenomicsGenomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells (ChIP-seq)
Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional plasticity and potential. Here we report the dynami...
ORGANISM(S): Mus musculus 
2011-06-21 | E-GEOD-27827 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP_chip]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30204 | biostudies-arrayexpress
TranscriptomicsGenomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells (RNA-seq)
Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional plasticity and potential. Here we report the dynami...
ORGANISM(S): Mus musculus 
2011-06-21 | E-GEOD-27843 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [RNA_seq]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-30280 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [strand-specific-RNA-seq]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-31385 | biostudies-arrayexpress
GenomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq].
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30203 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions.
This SuperSeries is composed of the following subset Series: GSE30202: DNA binding factors shape the mouse methylome at distal regulatory regions [BIS_seq] GSE30203: DNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq] GSE30204: DNA binding factors shape the mouse me...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30206 | biostudies-arrayexpress
TranscriptomicsAcetylation at the lateral surface of the nucleosome at lysine 64 of H3 regulates chromatin dynamics and defines transcriptionally active chromatin
Post-translational modifications of proteins have emerged as a major mechanism for regulating gene expression. Yet our understanding of how histone modifications directly affect chromatin function remains limited. Here, we investigate acetylation of histone H3 at lysine 64 (H3K64ac), a previously un...
ORGANISM(S): Mus musculus 
2014-03-18 | E-GEOD-35355 | biostudies-arrayexpress
UnknownApical Suspension Repair for Vaginal Vault Prolapse: A Randomized Clinical Trial.
Not available
S-EPMC11112501 | biostudies-literature
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.
Not available
S-EPMC12519944 | biostudies-literature
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