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TranscriptomicsPRC2 in Ewing tumors
We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem cells (Richter GH et al., Proc Natl Acad Sci U S A. 2009;106:5324-9). Downregulation of EZH2 by RNA interference in Ewing tumor cell lines suppressed oncogenic transf...
ORGANISM(S): Homo sapiens 
2009-04-29 | E-GEOD-15757 | biostudies-arrayexpress
TranscriptomicsRole of ICOS:ICOSL interaction in acute GVHD
Inducible co-stimulator (ICOS) interaction with its ligand (ICOSL) is involved in several T cell effector functions. While blockade of ICOS:ICOSL interaction in chronic graft versus host disease (GVHD) seems benefi cial, results for acute GVHD remain controversial. To further elucidate its role in a...
ORGANISM(S): Mus musculus 
2009-09-14 | E-GEOD-17995 | biostudies-arrayexpress
TranscriptomicsTargeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma
Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic trans...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-72673 | biostudies-arrayexpress
TranscriptomicsGene expression in pediatric cALL
Common ALL (cALL) is the most frequent entity of childhood ALL and carries an early pre-B cell phenotype. Expression patterns of 25 pediatric cALL samples were analyzed by use of high-density DNA microarrays HG-U133A. Leukemic patients’ bone marrow samples were compared to sorted B cells from cord...
ORGANISM(S): Homo sapiens 
2012-06-29 | E-GEOD-34670 | biostudies-arrayexpress
ModelsPassos2010_DNAdamage_CellularSenescence
This is the model described in: Feedback between p21 and reactive oxygen production is necessary for cell senescence. Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T. ;M...
2024-09-02 | BIOMD0000000287 | BioModels
TranscriptomicsGene expression profiles of Hodgkin’s lymphoma cell lines with different sensitivity to cytotoxic drugs
By using high-density DNA microarrays, we analyzed the gene-expression profile of Hodgkin's lymphoma cell lines. Furthermore, we tested the sensitivity of these cell lines for cytotoxic drugs (cisplatin, etoposide, melphalan) and compared the gene-expression profile of chemotherapy-resistant and -se...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-26325 | biostudies-arrayexpress
TranscriptomicsEpigenetic Maintenance of Stemness and Malignancy in Peripheral Neuroectodermal Tumors by EZH2
Chromatin modifications are increasingly recognized as a key mechanism in cancer. The histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) is the enzymatic subunit of the polycomb PRC2 complex and methylates histone H3K27, thereby, mediating gene silencing. Down-regulation of E...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-15890 | biostudies-arrayexpress
TranscriptomicsMondoA is highly expressed in acute lymphoblastic leukemia and modulates metabolism, differentiation and survival
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted treatment of childhood ALL, we performed a comprehensive transcriptome analysis yielding a set of genes specifically overexpressed in ALL. Among them we identified MondoA - a transcripti...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-33967 | biostudies-arrayexpress
TranscriptomicsGene expression in Ewing tumor cell lines after STEAP1 silencing
Goal: identification of differentially expressed genes after STEAP1 silencing. Ewing tumors (ET) are characterized by oncogenic EWS/ETS translocations and early metastasis. STEAP1 is a membrane-bound channel protein of unkown function. While overexpressed in many cancers, STEAP1 expression is strong...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-26422 | biostudies-arrayexpress
TranscriptomicsEwing sarcoma compared to a normal body map
Primary pediatric Ewing sarcoma (ES), one uncharacterized sarcoma as well as primary and well established ES cell lines were compared to probes of different normal tissues 8 Ewing sarcoma patient samples (MuET-x), 3 primary ES cell lines (SB-KMS-y), 3 well established ES cell lines (A673, SK-N-MC, R...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-45544 | biostudies-arrayexpress
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