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TranscriptomicsInflammatory gene expression in response to sub-lethal ricin exposure in Balb/c mice
The toxin ricin has been shown to cause inflammatory lung damage, leading to pulmonary oedema and, at higher doses, mortality. In order to understand the genetic basis of this inflammatory cascade a custom microarray platform (1509 genes) directed towards immune and inflammatory markers was used to ...
ORGANISM(S): Mus musculus 
2009-08-19 | E-GEOD-17431 | biostudies-arrayexpress
ProteomicsIdentification of Unknown Biological Toxin Protein Using Mass Spectrometry: A Case Study on De Novo Sequencing of Ricin
Currently, the genomes of many toxin proteins remain unsequenced. Characterizing these toxin proteins and their active peptide segments is crucial for the development of detoxification agents and for discovering proteins with potential therapeutic applications. Existing methods for identifying and d...
ORGANISM(S): Ricinus communis 
2025-12-01 | PXD061213 | Pride
Unknown biological toxin protein Heuristic denovo protein sequencing Ricin toxin De novo sequencing Mass spectrometry 
ProteomicsConstructing a Tandem Mass Spectral Library for Forensic Ricin Identification
Ricin, a protein found in castor seeds, is a lethal toxin that is designated as a category 2 select agent. Because castor seeds are easy to obtain and the toxin can be easily extracted, cases of attempted ricin poisoning are relatively common. A shotgun proteomics method for ricin identification has...
ORGANISM(S): Ricinus communis 
2019-10-02 | PXD013711 | Pride
Forensic proteomics Spectral library Castor Ricin Lc-ms/ms 
ProteomicsUniformly 15N-Labeled Recombinant Ricin A-chain as an Internal Retention Time Standard for Increased Confidence in Forensic Identification of Ricin by Untargeted Nanoflow Liquid Chromatog-raphy-Tandem Mass Spectrometry
Ricin, a toxic protein from the castor plant, is of forensic and biosecurity interest because of its high toxicity and common occurrence in crimes and attempted crimes. Qualitative methods to detect ricin are therefore needed. Untargeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) pr...
ORGANISM(S): Ricinus communis 
2020-07-16 | PXD015698 | Pride
Stable isotope labels  nitrogen-15 Ricin  forensics  retention time  standards 
TranscriptomicsTranscription profiling of human airway cells to ricin
Ricin is a potential bioweapon because of its toxicity, availability, and ease of production. When delivered to the lungs, ricin causes severe pulmonary damage with symptoms that are similar to those observed in acute lung injury and adult respiratory distress syndrome. The airway epithelium plays...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7845 | biostudies-arrayexpress
GenomicsExpression data of circRNAs from the Ricin Toxin-induced RAW264.7 macrophage cells
Expression data of circRNAs from the Ricin Toxin-induced RAW264.7 macrophage cells
PRJNA733103 | ENA
UnknownSensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin-Ab complexes.
Not available
S-EPMC7008010 | biostudies-literature
UnknownAutophagic Degradation Is Involved in Cell Protection against Ricin Toxin.
Not available
S-EPMC10222476 | biostudies-literature
UnknownRescue of rhesus macaques from the lethality of aerosolized ricin toxin.
Not available
S-EPMC6485354 | biostudies-literature
UnknownIdentification and Biological Evaluation of a Novel Small-Molecule Inhibitor of Ricin Toxin.
Not available
S-EPMC11012547 | biostudies-literature
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