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MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
TranscriptomicsGenomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa
Comparison of gene expression between the virulent Rickettsia rickettsii R strain and avirulent Rickettsia rickettsii Iowa. Keywords: virulent vs avirulent Virulent Rickettsia rickettsii R strain in triplicate was compared to avirulent Rickettsia rickettsii Iowa in triplicate
ORGANISM(S): Rickettsia rickettsii 
2010-05-26 | E-GEOD-8041 | biostudies-arrayexpress
ProteomicsEndothelial cell proteomic response to Rickettsia conorii infection
Rickettsia conorii is the etiologic agent of Mediterranean spotted fever, a re-emerging disease with significant mortality. This obligate, gram-negative intracellular pathogen is transmitted via tick bites, resulting in disseminated vascular endothelial cell infection with vascular leakage. In the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080856 | MassIVE
ProteomicsRickettsia slovaca intra cellular bacteria global proteome
Semi quantitative intracellular bacteria proteome using a 2D nanoLC-M/MS analysis system enabling a maximum sample exploration. This setup was helpful to analyse this complex sample composed of peptides from the studied bacteria and its host. Sample was doped before injection in order to calculate p...
ORGANISM(S): Rickettsia slovaca (strain 13-B) 
2018-10-25 | PXD003195 | Pride
Hdmse Xenopus laevis Rickettsia Hi3 
ProteomicsRickettsia raoultii intra cellular bacteria global proteome
Semi quantitative intracellular bacteria proteome using a 2D nanoLC-M/MS analysis system enabling a maximum sample exploration. This setup was helpful to analyse this complex sample composed of peptides from the studied bacteria and its host. Sample was doped before injection in order to calculate p...
ORGANISM(S): Rickettsia raoultii Xenopus laevis (African clawed frog) 
2018-10-25 | PXD003193 | Pride
Hdmse Xenopus laevis Rickettsia Hi3 
TranscriptomicsR. conorii transcriptional response within inoculation eschar battlefield
Rickettsia conorii, the causative agent of the MSF is transmitted to humans by the bite of infected ticks Rhipicephalus sanguineus. The skin thus constitutes an important barrier for the entry and propagation of R. conorii. Given this, analysis of the survival strategies used by the bacterium within...
ORGANISM(S): Rickettsia conorii 
2008-11-06 | E-GEOD-12130 | biostudies-arrayexpress
ProteomicsRickettsia conorii intra cellular bacteria global proteome
Semi quantitative intracellular bacteria proteome using a 2D nanoLC-M/MS analysis system enabling a maximum sample exploration. This setup was helpful to analyse this complex sample composed of peptides from the studied bacteria and its host. Sample was doped before injection in order to calculate p...
ORGANISM(S): Rickettsia conorii (strain ATCC VR-613 / Malish 7) 
2018-10-25 | PXD003194 | Pride
Hdmse Xenopus laevis Rickettsia Hi3 
ProteomicsRickettsia massiliae intra cellular bacteria global proteome
Semi quantitative intracellular bacteria proteome using a 2D nanoLC-M/MS analysis system enabling a maximum sample exploration. This setup was helpful to analyse this complex sample composed of peptides from the studied bacteria and its host. Sample was doped before injection in order to calculate p...
ORGANISM(S): Rickettsia massiliae (strain Mtu5) Xenopus laevis (African clawed frog) 
2018-10-25 | PXD003197 | Pride
Hdmse Xenopus laevis Rickettsia Hi3 
GenomicsRickettsia
Rickettsia Genome sequencing and assembly
PRJNA1234396 | ENA
GenomicsRickettsia rickettsii
Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa
PRJNA100859 | ENA
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