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ProteomicsGel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons
Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and correlates with neurodegeneration in both diseases. In disease, characteristic C-terminal fragments of ~25 kDa ("TDP-25") accumulate in cytoplasmic i...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-08 | PXD031083 | Pride
Als / neurodegeneration / phase separation / proteasome / tdp-43 
ProteomicsGel-like inclusions of C-terminal fragments of TDP-43 sequester and inhibit proteasomes
TDP-43 inclusions enriched in C-terminal terminal fragments of ~25 kDa ("TDP-25") are associated with neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we analyzed gain-of-function mechanisms of TDP-25 combining cryo-electron tomography, proteomics and...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-04-14 | PXD024358 | Pride
Proteomics Proteasomes Tdp-43 Als Ftd 
TranscriptomicsDNA Methylation Profiling of Human Saliva
Background: Low birth weight is associated with an increased adult metabolic disease risk. It is widely discussed that poor intrauterine conditions could induce long-lasting epigenetic modifications, leading to systemic changes in regulation of metabolic genes. In a unique cohort of 17 monozygotic (...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-39560 | biostudies-arrayexpress
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
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