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GenomicsLipid-anchored Proteasomes Control Membrane Protein Homeostasis
Lipid-anchored Proteasomes Control Membrane Protein Homeostasis
PRJNA971586 | ENA
GenomicsAKIRIN2 controls the nuclear import of proteasomes in vertebrates
AKIRIN2 controls the nuclear import of proteasomes in vertebrates
PRJNA662348 | ENA
ProteomicsDigestion of a variety of synthetic peptides by proteasomes
Proteasomes are large multi-subunit enzymes that act as the main producers of antigenic peptides presented at the cell surface to CD8+ T cells. They can simply cut proteins or recombine their fragments thereby generating novel sequences, i.e. spliced peptides via a process called proteasome-catalyse...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD016782 | Pride
Synthetic peptides Proteasome Digestion Lc-ms/ms 
ProteomicsSelective microautophagy of proteasomes is initiated by ESCRT-0 and is promoted by proteasome ubiquitylation
The proteasome is central to proteolysis by the ubiquitin-proteasome system under normal growth conditions but is itself degraded through macroautophagy under nutrient stress. A recently described AMPactivated protein kinase (AMPK)-regulated endosomal sorting complex required for transport (ESCRT)-d...
ORGANISM(S): Saccharomyces Cerevisiae 
2022-02-06 | PXD031469 |
ProteomicsMyelin basic protein fragmentation by engineered human proteasomes with different catalytic phenotypes revealed direct peptide ligands of MS-associated and protective HLA class I molecules
Proteasomes exist in mammalian cells in multiple combinatorial variants due to the broadly diversified regulatory particles and catalytic subunits exchange. Here, using biotin carboxyl carrier domain of transcarboxylase from Propionibacterium shermanii fused with different proteasome subunits of cat...
ORGANISM(S): Homo sapiens (Human) 
2023-01-13 | PXD038387 | Pride
Human Lc-msms Mbp Proteosome 
ProteomicsActivity-Guided Proteomic Profiling of Proteasomes
A composition of proteasome complexes in WT yeast, and the changes these complexes undergo upon the deletion of Pre9 (Δα3) or of Sem1 (ΔSem1) based on whole-cell proteomic analysis and to activity-guided proteasome profiling of indicates that the amounts of proteasomal proteins and proteasome intera...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-15 | PXD045051 | Pride
Activity-guided profilling Proteasome 
ProteomicsActivity-Guided Proteomic Profiling of Proteasomes - Whole proteome studies
A composition of proteasome complexes in WT yeast, and the changes these complexes undergo upon the deletion of Pre9 (Δα3) or of Sem1 (ΔSem1) based on whole-cell proteomic analysis and to activity-guided proteasome profiling of indicates that the amounts of proteasomal proteins and proteasome intera...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-15 | PXD045047 | Pride
Activity-guided profilling Proteasome 
ProteomicsGel-like inclusions of C-terminal fragments of TDP-43 sequester and inhibit proteasomes
TDP-43 inclusions enriched in C-terminal terminal fragments of ~25 kDa ("TDP-25") are associated with neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we analyzed gain-of-function mechanisms of TDP-25 combining cryo-electron tomography, proteomics and...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-04-14 | PXD024358 | Pride
Proteomics Proteasomes Tdp-43 Als Ftd 
UnknownBacterial Proteasomes.
Not available
S-EPMC4702487 | biostudies-literature
TranscriptomicsAKIRIN2 controls the nuclear import of proteasomes in vertebrates
Protein expression and turnover are controlled through a complex interplay of transcriptional, post-transcriptional and post-translational mechanisms to enable spatial and temporal regulation of cellular processes. To systematically elucidate such gene regulatory networks, we developed a CRISPR scre...
ORGANISM(S): Homo sapiens 
2021-08-27 | GSE157663 | GEO
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