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TranscriptomicsTranscription profiling of human dendritic monocytes treated with LPS (lipopolysaccharide) or CyP (Cyanobacterial Product) reveals cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. We report the identification and biologic characterization of an LPS-like molecule extracted from the cyanobacterium Oscillatoria Planktothrix FP1 (CyP).
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4748 | biostudies-arrayexpress
TranscriptomicsThe novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models
we report characterized the preclinical activity of a new member of this class, the ST1926-derivative ST5589, in lymphomas GEP analysis of 2 lymphoma cell lines with and without treatment
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-66455 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing analysis of senescence in Mus musculus prostate cancer models
Acute Pten loss initiates prostate tumorigenesis characterized by cellular senescence response. Here we examine the cellular senescence response in epithelial individual cells, by single-cell RNA sequencing (scRNAseq) in Ptenpc-/- and Ptenpc-/-; Timp1-/- GEMMs. ScRNAseq analysis determines a cluste...
ORGANISM(S): Mus musculus 
2020-10-09 | E-MTAB-9578 | biostudies-arrayexpress
TranscriptomicsA20 IN MARGINAL ZONE LYMPHOMAS
Unique and shared cytogenetic abnormalities have been documented for marginal zone lymphomas (MZLs) arising at different sites. Recently, homozygous deletions of the chromosomal band 6q23, involving the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kap...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-13989 | biostudies-arrayexpress
MetabolomicsHif1α-Dependent Uncoupling Of Glycolysis Suppresses Tumor Cell Proliferation
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
TranscriptomicsTranscription profiling of human dendritic cells to identify a combinatorial code by which DCs discriminate pathogens and provide (suggest) a rationale to design adjuvants for TH1 responses.
Toll like receptors (TLRs) sense microbial products and initiate adaptive immune responses by activating dendritic cells (DCs). Since pathogens may contain several agonists we asked whether different TLRs may synergize in DC activation. We report that in human and mouse DC TLR3 or TLR4 potently syne...
ORGANISM(S): Homo sapiens 
2007-09-14 | E-GEOD-2706 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of humans to investigate between transient vs acute megakaryoblastic leukaemia (TMD vs AMKL) in Downs syndrome
Comparison of transient myeloproliferative disorder and acute megakaryoblastic leukaemia in Down syndrome.
ORGANISM(S): Homo sapiens 
2004-09-01 | E-MEXP-72 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for Marginal Zone Lymphoma samples
Marginal zone B-cell lymphomas (MZL) have been divided into three distinct subtypes (extranodal MZL of MALT type, nodal MZL; splenic MZL). Nevertheless, the relationship between them is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of ...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-24881 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of Richter-syndrome Chronic Lymphocytic Leukemia
Richter syndrome (RS) occurs in up to 15% of patients with chronic lymphocytic leukemia (CLL). While RS, usually represented by the histologic transformation to a diffuse large B-cell lymphoma (DLBCL), is associated with a very poor outcome, especially when clonally related to the pre-existing CLL, ...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-GEOD-50252 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of Anaplastic Large Cell Lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is a mature T-cell lymphoma that can present as a systemic or primary cutaneous disease. Systemic ALCL represents 2-5% of adult lymphoma but up to 30% of all pediatric cases. Two subtypes of systemic ALCL are currently recognized on the basis of the presence of ...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-GEOD-50253 | biostudies-arrayexpress
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