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Endometrial biopsies from tumor (T), adjacent normal (N) and hyperplastic (H) tissue specimens (when available) were obtained by histeroscopy from 10 patients and 3 healty donor. RNA isolated from these samples was used to perform smallRNA-Seq by NGS and gene expression profiling by microarrays in ...
ORGANISM(S): Homo sapiens 
Endometrial biopsies from tumor (T), adjacent normal (N) and hyperplastic (H) tissue specimens were obtained by histeroscopy from 5 patients
ORGANISM(S): Homo sapiens 
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. We report the identification and biologic characterization of an LPS-like molecule extracted from the cyanobacterium Oscillatoria Planktothrix FP1 (CyP).
ORGANISM(S): Homo sapiens 
Toll like receptors (TLRs) sense microbial products and initiate adaptive immune responses by activating dendritic cells (DCs). Since pathogens may contain several agonists we asked whether different TLRs may synergize in DC activation. We report that in human and mouse DC TLR3 or TLR4 potently syne...
ORGANISM(S): Homo sapiens 
Our previous work has shown that exogenous DNA impose a burden to the host cells due to the finite amount of transcriptional and translational resources, resulting in a limiting productivity capacity. We thus designed context-aware genetic networks in which miRNAs were successfully exploited as burd...
ORGANISM(S): Homo sapiens 
Obesity represents a risk factor for breast cancer development and therapy resistance, but the molecular players underling these links are unclear. Here, we identify a role for the obesity-cytokine leptin in sustaining aromatase inhibitor (AI) resistant growth and progression in breast cancer. Using...
ORGANISM(S): Mus musculus 
Cancer-associated fibroblasts (CAFs), the principal components of tumor microenvironment, play multiple roles in breast cancer onset and progression. While their impact is widely accepted, treatment options to target CAFs in clinical practice were not yet well established. The nuclear receptor supe...
ORGANISM(S): Homo sapiens 
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