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MetabolomicsPeroxide antimalarial treatment timecourse on ring-stage P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001202 | MetabolomicsWorkbench
TranscriptomicsEffects of physiological and synthetic IAP antagonism on c-IAP dependent signaling
Cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2) play central roles in signal transduction mediated by numerous receptors that participate in inflammatory and immune responses. In certain pathways, such as activation of NF-kB, their degradation is a major regulatory event and is physiolog...
ORGANISM(S): Homo sapiens 
2015-02-09 | E-GEOD-64927 | biostudies-arrayexpress
TranscriptomicsIn vitro antiplasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent and gene expression profiling.
To determine the transcriptional effects of a novel plant-based compound, dehydrobrachylaenolide, on P. falciparum, parasite cultures were treated with the compound over time. Samples were taken for analysis 2, 6, and 12 hours post-invasion of human red blood cells. Control cultures were treated sim...
ORGANISM(S): Plasmodium falciparum 3D7 
2011-11-01 | E-GEOD-29874 | biostudies-arrayexpress
TranscriptomicsNodal Root Bud Development - Transcriptome Analysis
Bioenergy sorghum’s large and deep nodal root system and associated microbiome enables uptake of water and nutrients from and deposition of soil organic carbon into soil profiles, key contributors to the crop’s resilience and sustainability. The goal of this study was to increase our understanding o...
ORGANISM(S): Sorghum bicolor 
2025-05-10 | E-MTAB-15090 | biostudies-arrayexpress
TranscriptomicsGene expression profile of a S. cerevisiae strain deleted in CSN5/RRI1 gene (systematic name YDL216C)
The COP9 signalosome (CSN) is a highly conserved eukaryotic protein complex which regulates the Cullin-RING family of ubiquitin ligases and carries out a deneddylase activity that resides in subunit 5 (CSN5). The budding yeast CSN is biochemically active and deletion mutants of each of its subunits ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-23 | E-GEOD-51563 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate
Each experiment consisted in an artesunate-free culture (control) and an artesunate treated culture. For each time point explored, cDNA from parasites with and without the drug were labeled with different cyanines, mixed and hybridized. To analyse dynamic transcriptome alterations, two pilot experim...
ORGANISM(S): Plasmodium falciparum 
2008-06-01 | E-MEXP-1435 | biostudies-arrayexpress
MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
ProteomicsReduced structural rigidity of MDMX protein enhances binding to TP53 mRNA
The two murine double minute (MDM) family members, MDM2 and MDMX are a well-established negative regulator of p53 activity. Under DNA damage conditions, MDM2 and MDMX are phosphorylated near their RING domains (serine 395 at MDM2 and serine 403 at MDMX) and switch to act as p53 positive regulators. ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD060074 | Pride
Human Mdmx-mdm2 interaction P53 mrna stabilization Ring domain Hdx-ms mapping Lc-ms/ms 
UnknownGenome-wide assessment and mapping of inbreeding depression identifies candidate genes associated with semen traits in Holstein bulls.
Not available
S-EPMC10157977 | biostudies-literature
GenomicsH3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Ring1b_ChIP]
The goal of this study is to understand the genome-wide alterations in chromatin landscape induced by a histone mutation (H3.3K36M) derived from chondroblastomas Examination of genome-wide Ring1b distribution in cells expressing H3.3WT and H3.3K36M.
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-69286 | biostudies-arrayexpress
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