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GenomicsMouse ES cells expressing catalytically inactive Ring1B display impaired Ring1B and H3K27me3 deposition.
ChIP-seq for H3K27me3 and Ring1B was performed in WT mESCs and mESCs containing catalytically inactive Ring1B (I53A mutant). Cells expressing catalytically inactive Ring1B maintain the spatial distribution of Ring1B and H3K27me3 but at reduced levels. These findings support the notion that PRC2 recr...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-69955 | biostudies-arrayexpress
TranscriptomicsCatalytically inactive Ring1B maintains near wildtype levels of gene expression in mESCs
This experiment was designed to determine the extent of gene misregulation in mESCs containing catalytically dead Ring1B in comparison to mESCs lacking Ring1B. Polyadenylated mRNA was prepared from wildtype mESCs (WT), mESCs deficient for Ring1B (KO) and mESCs cells containing catalytically dead Rin...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-69824 | biostudies-arrayexpress
TranscriptomicsChIP for H3K27me3 in Murine ES Cells: wild type and Ring1B-/- cells
Native ChIP on chip for H3K27me3 in murine ES cells comparing WT and Ring1B-/- cells. Paper Abstract: How polycomb group proteins repress gene expression in vivo is not known. Whilst histone modifying activities of the polycomb repressive complexes have been studied extensively, in vitro data has su...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-20213 | biostudies-arrayexpress
TranscriptomicsRing1b profiling in pancreatic islets
To gain insights into how pancreatic cells are programmed in vivo, we profiled RNA expression in pancreatic islets of pancreatic Ring1b conditional KO mice (conditional using a pancreas specfic Cre; Pdx1-Cre) and their littermate controls
ORGANISM(S): Mus musculus 
2013-02-10 | E-MTAB-1404 | biostudies-arrayexpress
GenomicsRING1B binding in the 11 dpc embryonic tissues
We report the distribution of RING1B (one of Polycomb group factors) within the genome of mouse embryonic tissues. We prepared the chromatin from 11 dpc embryonic forebrain, midbrain, and forelimb buds and made chromatin precipitation with antibody against RING1B (mouse monoclonal antibody). High-th...
ORGANISM(S): Mus musculus 
2014-01-14 | E-GEOD-48464 | biostudies-arrayexpress
ModelsNguyenLK2011 - Ubiquitination dynamics in Ring1B/Bmi1 system
NguyenLK2011 - Ubiquitination dynamics in Ring1B-Bmi1 system This theoretical model investigates the dynamics of Ring1B/Bmi1 ubiquitination to identify bistable switch-like and oscillatory behaviour in the system. Michaelis-Menten (MM) equations are used to formulate the model. However, the authors ...
2024-09-02 | BIOMD0000000622 | BioModels
TranscriptomicsRing1b profiling in pancreatic islets
To gain insights into how pancreatic cells are programmed in vivo, we profiled Ring1b in embryonic stem cells and pancreatic islets
ORGANISM(S): Mus musculus 
2013-01-04 | E-MTAB-1402 | biostudies-arrayexpress
ProteomicsLFQMS of RING2 (RING1B, RNF2) immunoprecipitation from MDA-MB-231 and T47D breast cancer cells
Polycomb repressive complex PRC1 is essential for gene regulation in numerous cell fate decisions. We show that RING1B (RING2, RNF2) and canonical PRC1 (cPRC1) genes are amplified and overexpressed in breast cancer (BC). Moreover, cPRC1 complexes functionally associate with genes regulated by cell t...
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD009570 | Pride
Lc-msms lfqms ip-ms ap-ms ring2 
GenomicsGenome-wide RING1B binding in Fbxl10 overexpressing 3T3-L1 cells at day 2 of differentiation
We analyzed RING1B binding regions in 3T3-L1 cell lines transduced with the retroviral vector for V5-tagged Fbxl10 or its dF-box mutant. RING1B ChIP-seq in empty, Fbxl10-1, and dF-box mutant vector transduced 3T3-L1 preadipocytes, in duplicate, and V5-Fbxl10 ChIP-seq in Fbxl10 overexpressing 3T3-L1 ...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64312 | biostudies-arrayexpress
TranscriptomicsMurine Embryonic Stems Cells: H3K27me3 in Undifferentiated (UD) and Day 3 (D3) differentiated ES cells
ChIP on chip for H3K27me3 in murine ES cells comparing Undifferentiated and Day 3 differentiated. Paper Abstract: How polycomb group proteins repress gene expression in vivo is not known. Whilst histone modifying activities of the polycomb repressive complexes have been studied extensively, in vitro...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-20201 | biostudies-arrayexpress
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