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TranscriptomicsOrchestrated intron retention regulates normal granulocyte differentiation [RNA-Seq]
Using mRNA-seq, we determined intron retaining genes that were differentially regulated in FACS purified cells at three progressive stages of mouse granulopoiesis; CD34+Kit+Gr-1low promyelocytes, CD34-Kit-Gr-1mid myelocytes and CD34-Kit-Gr-1high granulocytes. We found that IR affects 86 genes, inclu...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48305 | biostudies-arrayexpress
TranscriptomicsOrchestrated intron retention regulates normal granulocyte differentiation [Affymetrix arrays]
Using mRNA-seq, we determined intron retaining genes that were differentially regulated in FACS purified cells at three progressive stages of mouse granulopoiesis; CD34+Kit+Gr-1low promyelocytes, CD34-Kit-Gr-1mid myelocytes and CD34-Kit-Gr-1high granulocytes. We found that IR affects 86 genes, inclu...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48306 | biostudies-arrayexpress
TranscriptomicsGene expression profile of influenza virus antigen-activated or in vitro stimulated murine CD8+ T cells on day 7
The precise timing and pathway of memory CD8+ T cells differentiation from naïve T cells have remained undetermined. We found the smaller cell-size and slower cell cycling cells were segregated from the proliferative larger cell-size activated T cell pool at the peak of infection. Gene signature of ...
ORGANISM(S): Mus musculus 
2015-02-25 | E-GEOD-48219 | biostudies-arrayexpress
TranscriptomicsOrchestrated intron retention regulates normal granulocyte differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48307 | biostudies-arrayexpress
TranscriptomicsIn vivo LPS responses in murine splenic CD8 and CD11b DC subsets
Background: Dendritic cells (DCs) are critical for regulating CD4 and CD8 T cell immunity, controlling Th1, Th2, and Th17 bias, generating inducible Tregs, and inducing tolerance. Multiple DC subsets have been identified in the mouse that are thought to have evolved to control these different immune...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-42573 | biostudies-arrayexpress
UnknownAdding Celecoxib With or Without Zoledronic Acid for Hormone-Naive Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial.
Not available
S-EPMC5455701 | biostudies-literature
TranscriptomicsA Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment
Confusion arising from the attribution of divergent functions to similar cell types from the mononuclear phagocyte system is mainly due to difficulties in identifying or distinguishing different dendritic cells (DC), macrophages or monocyte subsets and/or their activation states. Using an extensive ...
ORGANISM(S): Mus musculus 
2017-08-16 | E-MTAB-5932 | biostudies-arrayexpress
TranscriptomicsPancreatic Gene Expression from Wild-Type, Stat1-Transgenic, and Stat1-CC-Transgenic Mice
Pancreatic Gene Expression from Wild-Type, Stat1-Transgenic, and Stat1-CC-Transgenic Mice. This data was part of the set of data utilized to identify PARP9/DTX3L as a novel antiviral gene. Keywords: transgene state analysis RNA was extracted from the pancreas of 3 mice per genotype (wild-type, Stat1...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-61414 | biostudies-arrayexpress
TranscriptomicsEffects of Active or Inactive PARP9/DTX3L Overexpression on ISG Expression
U3A cells expressing Stat1 were transfected with either wild-type PARP9 and DTX3L, or inactive mutants of PARP9 and DTX3L. Stable lines were assessed for gene expression to identify effects of PARP9/DTX3L overexpression on ISG expression. Keywords: interferon, PARP9, DTX3L, antiviral RNA was isolate...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-61411 | biostudies-arrayexpress
TranscriptomicsModified Stat1 Confers Enhanced Interferon Responsiveness and Improved Baseline Antiviral Host Defense
U3A cells stably expressing wild-type STAT1 or STAT1-CC were treated with interferon beta (10U/ml) or control for 24 hours to assess effects of stat1 modifications, interferon, and the interaction on gene expression. Keywords: interferon, STAT1, STAT1-CC, STAT1CC, STAT-1C, antiviral RNA was isolated...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-61413 | biostudies-arrayexpress
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