Sort   by:  
 Page size 
ProteomicsHECTD3 is a small HECT E3 ligase with unique features
HECT E3 ligases regulate many cellular processes, yet how they recognise their substrates and synthesise specific types of poly-ubiquitin chains is still incompletely understood. HECTD3, a member of the “other HECT” family, is implicated in the regulation of inflammation, apoptosis, and infection an...
ORGANISM(S): Homo sapiens (Human) 
2026-01-15 | PXD066996 | Pride
E3 ligase Cross-linking 
ProteomicsCovalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2
As the global fight against antimicrobial resistance in bacteria becomes increasingly pressing, new tool compounds are needed to understand and identify novel therapeutic targets. Here, cysteine-directed fragment-based drug discovery is coupled with a high throughput chemistry direct-to-biology scre...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD057304 | Pride
Bacterial nels Fragment-based drug discovery Covalent fragments Salmonella effectors Chemoproteomics E3 ligase High throughput chemistry 
ProteomicsSalmonella effector kinase SteC is activated by host-mediated phosphorylation
The pathogen Salmonella, which causes significant human morbidity and mortality, encodes an effector kinase, SteC, which mediates actin polymerisation and cell migration of the infected cell. Analysis of the sequence and predicted structure alongside canonical eukaryotic serine-threonine kinases rai...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. T000240 
2026-06-12 | PXD061217 | Pride
Bacterial kinase Hdx Stec Effector Phosphorylation Salmonella Host-pathogen interactions Kinase regulation Non-rd kinase 
ProteomicsBacterial effectors mediate kinase reprogramming through a series of evolutionary conserved amino acids that mimic eukaryotic motifs
Bacteria have evolved numerous biochemical processes that underpin their biology and pathogenesis. The small, non-enzymatic bacterial (Salmonella) effector SteE mediates kinase reprogramming, whereby the canonical serine/threonine host kinase GSK3 gains tyrosine-directed activity towards neosubstrat...
ORGANISM(S): Salmonella sp. WT 
2025-04-25 | PXD058368 | Pride
Mass spectrometry Hdx Kinase 
Sort   by:  
 Page size