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TranscriptomicsVariation in gene expression patterns in follicular lymphoma and the response to rituximab
This SuperSeries is composed of the following subset Series: GSE3646: Follicular lymphoma and normal lymphoid tissue comparisons GSE3647: Follicular lymphoma lymph node Abstract: Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors...
ORGANISM(S): Homo sapiens 
2006-03-06 | E-GEOD-4351 | biostudies-arrayexpress
TranscriptomicsAntitumoral activity of acadesine and rituximab in MCL
Acadesine is a nucleoside analogue with known antileukemic effects in different neoplasms. We investigated the activity of acadesine ne exerts a cytotoxic effect in MCL and synergizes with rituximab supporting clinical examination of this strategy for MCL patients We used microarrays to detail the g...
ORGANISM(S): Homo sapiens 
2013-06-13 | E-GEOD-47871 | biostudies-arrayexpress
Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human follicular lymphoma and normal lymphoid tissue comparisons
20 FL lymph node samples from 16 patients and four normal lymphoid tissues (two tonsil and two spleen) from four different patient. Data can be viewed on the supplemental website at http://genome-www.stanford.edu/rituximab/.
ORGANISM(S): Homo sapiens 
2005-10-05 | E-SMDB-1845 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of human leukemic B-cells.
Fresh blood samples were collected from 10 CLL (chronic lymphocytic leukemia) previously untreated patients before and after 2 weeks of the first cycle of CCR (cladribine, cyclophosphamide, rituximab) treatment. Peripheral blood mononuclear cells (PBMNCs) were separated from EDTA blood by layering o...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-33925 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing from human salivary glands from Sjogren's disease patients recruited in the TRACTISS randomized clinical trial
Sjogren's disease patients received Rituximab (anti-CD20 depleting monoclonal antibody) or placebo treatment. This study aims to identify the transcriptomic features of salivary gland biopsies, the target tissue of the autoimmune response in Sjögren’s disease. It examines transcriptomic changes in s...
ORGANISM(S): Homo sapiens 
2025-06-30 | E-MTAB-15225 | biostudies-arrayexpress
TranscriptomicsFollicular lymphoma and normal lymphoid tissue comparisons
20 FL lymph node samples from 16 patients and four normal lymphoid tissues (two tonsil and two spleen) from four different patient. Data can be viewed on the supplemental website at http://genome-www.stanford.edu/rituximab/. Set of arrays organized by shared biological context, such as organism, tu...
ORGANISM(S): Homo sapiens 
2005-11-22 | E-GEOD-3646 | biostudies-arrayexpress
TranscriptomicsEffect on peripheral blood gene expression profile of lenalidomide plus rituximab in patients with follicular lymphoma
Peripheral blood was collected into PAXgene tubes from 7 patients with follicular lymphoma, in a phase 2 clinical trial of lenalidomide plus rituximab as initial therapy for advanced-stage indolent non-Hodgkin's lymphoma. Blood was collected at baseline and on Day 15 of the second 28-day cycle, for ...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-54740 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human B cell lymphoma cell lines in response to rituximab treatment
HF-1, Granta-519, SUDHL4,Oci-Ly10 and Oci-Ly3 cell lines, representing different B cell lymphoma subtypes, were induced with rituximab (R) for three hours and analyzed for differentially expressed genes compared to untreated control.
ORGANISM(S): Homo sapiens 
2010-06-22 | E-MEXP-2317 | biostudies-arrayexpress
TranscriptomicsAntibody mRNA-seq repertoire sequencing to study relapses after B-cell depletion therapy
Rituximab (RTX) is widely used as a first-line therapeutic strategy for patients affected by immune thrombocytopenia (ITP). However, a large proportion of patients relapse after successful treatment. The present NGS assay was done to help find the cause for this relapse on the immune repertoire leve...
ORGANISM(S): Homo sapiens 
2021-01-18 | E-MTAB-9953 | biostudies-arrayexpress
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