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TranscriptomicsA role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing
Epigenetic silencing of transposons by Piwi-interacting RNAs (piRNAs) constitutes an RNA-based genome defense mechanism. Piwi endonuclease action amplifies the piRNA pool by generating new piRNAs from target transcripts by a poorly understood mechanism. Here, we identified mouse Fkbp6 as a factor in...
ORGANISM(S): Bombyx mori 
2012-09-04 | E-GEOD-39203 | biostudies-arrayexpress
TranscriptomicsRNA-seq of HeLa cells to investigate regulation of replicative histone RNA metabolism by the histone chaperone ASF1
Histones are the protein components of the basic unit of chromatin, the core particle of the nucleosome. They play a central role in defining chromatin states associated with distinct cell fates and are classified into replicative and non-replicative/replacement histone variants. While the latter do...
ORGANISM(S): Homo sapiens 
2023-11-29 | E-MTAB-12501 | biostudies-arrayexpress
TranscriptomicsHIRA, a Conserved Histone Chaperone, Plays an Essential Role in Low-dose Stress Response via Transcriptional Stimulation in Fission Yeast
Cells that have been pre-exposed to mild stress (priming stress) acquire transient resistance to subsequent severe stress even under different combinations of stresses. This phenomenon is called cross-tolerance. Although it has been reported that cross-tolerance occurs in many organisms, the molecul...
ORGANISM(S): Schizosaccharomyces pombe 
2012-07-21 | E-GEOD-35281 | biostudies-arrayexpress
ProteomicsRNA-dependent solubility of Escherichia coli proteome: Structural hub, disorder, and chaperone network
Protein aggregation is a complex phenomenon involving aberrant folding and proteostasis that leads to various proteopathies. Despite extensive efforts, the maintenance of protein solubility against aggregation remains ill-defined, especially in complex cellular environments. In this study, we show t...
ORGANISM(S): Escherichia coli 
2024-05-24 | PXD040618 | Pride
Rna Chaperone Aggregation Protein folding Proteomics Lc-ms/ms 
TranscriptomicsTotal RNA-seq in WT and HIRA KO HeLa cells
We performed total RNA-seq of G1/S-synchronised HeLa cells that are wild-type (WT) or knock-out (KO) for the H3.3-specific chaperone HIRA and bear an exogenous H3.1-SNAP and H3.3-SNAP gene.
ORGANISM(S): Homo sapiens 
2025-08-07 | E-MTAB-14417 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hip1::ura4+ and slm9::ura4+ S. pombe to investigate the role of the HIRA histone chaperone complex
The assembly of nucleosomes by histone chaperones is an important component of transcriptional regulation. Here we have assessed the global roles of the S. pombe HIRA histone chaperone complex. Microarray analysis indicates that inactivation of the HIRA complex results in increased expression of at ...
ORGANISM(S): Schizosaccharomyces pombe 
2009-07-22 | E-MTAB-130 | biostudies-arrayexpress
GenomicsGenome-wide maps of WT and over-expressing CenH3/CENP-A in Human HeLa S3 cells
Centromeres are essential to ensure proper chromosome segregation in eukaryotes. Their definition relies on the presence of a centromere-specific H3 histone variant CenH3, known as CENP-A in mammals. Its overexpression in aggressive cancers raises questions concerning its effect on chromatin dynamic...
ORGANISM(S): Homo sapiens 
2014-02-12 | E-GEOD-42951 | biostudies-arrayexpress
UnknownRNA melting and RNA chaperone activities of plant cold shock domain proteins are not correlated.
Not available
S-EPMC6161695 | biostudies-literature
TranscriptomicsEffect of a cardiomyocyte-specific Hira conditional knockout on gene expression in the heart
We performed gene expression profiling by microarray using RNA extracted from healthy free wall left ventricle tissues from control and Hira cardiomyocyte-specific conditional knockout mice at 6 weeks of age. Hira is a histone chaperone responsible for replication-independent incorporation of histo...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-71833 | biostudies-arrayexpress
UnknownBinding of the RNA Chaperone Hfq on Target mRNAs Promotes the Small RNA RyhB-Induced Degradation in Escherichia coli.
Not available
S-EPMC8544716 | biostudies-literature
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