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MetabolomicsGut Commensal Bacteria-Derived Methionine is Required for Host Reproduction by Modulating RNA m6A Methylation of the Insulin Receptor_targeted metabolites

Gut commensal bacteria promote host reproduction by modulating metabolism and nutrition, but the molecular mechanisms by which microbes regulate reproduction remain unclear. Here, we show that gut commensal bacteria promote host reproduction by providing amino-acid methionine, which controls the ...

2025-06-22 | MTBLS12470 | MetaboLights
MetabolomicsSystemic Inflammation Induces Cholestasis via Upregulating a Short Variant of FTO to Remove the m6A Methylation in the 3’-UTR of Cyp7b1 mRNAs in liver
The cholestasis frequently occurs in patients with inflammatory processes. However, the mechanisms of inflammation in inducing cholestasis are still unclear. Here, by using lipopolysaccharide (LPS)-induced cholestasis mouse models, we found that most genes encoding enzymes responsible for bile acid ...
2025-11-07 | MTBLS10713 | MetaboLights
TranscriptomicsSmall RNA mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation
Mammalian cells contain copious amounts of RNA including both coding and non-coding RNA (ncRNA). Generally the ncRNAs function to regulate gene expression at the transcriptional and post-transcriptional level. Among ncRNA, the long ncRNA and small ncRNA can affect histone modification, DNA methylati...
ORGANISM(S): Homo sapiens 
2015-04-21 | E-GEOD-68027 | biostudies-arrayexpress
TranscriptomicsDNA methylation distinguishes pathologically normal human tissues
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividual epigenetic variation in normal tissues due to aging...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19434 | biostudies-arrayexpress
GenomicsPolymerase-IV occupancy at RNA-directed DNA methylation sites requires SHH1
DNA methylation is an epigenetic modification that plays critical roles in gene silencing, development, and the maintenance of genome integrity. In Arabidopsis, DNA methylation is established by DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) and is targeted by 24 nt small interfering RNAs (siRNAs) th...
ORGANISM(S): Arabidopsis thaliana 
2013-05-13 | E-GEOD-45368 | biostudies-arrayexpress
TranscriptomicsDNA methylation and expression profiling study for prostate cancer
Microarray-based DNA methylation and gene expression profiling was carried out using a panel of prostate cancer cell lines (LNCaP-FGC, DU-145, and PC-3) and the control normal prostate RWPE1 cell line. The identification of prostate cancer-specific methylation markers was based on the following crit...
ORGANISM(S): Homo sapiens 
2011-07-24 | E-GEOD-23388 | biostudies-arrayexpress
GenomicsAn IDN2-containing complex involved in RNA-directed DNA methylation in Arabidopsis [BS-seq]
Illumina-based whole genome bisulfite sequencing libraries for 4 RNA-directed DNA methylation mutants Examining DNA methylation levels in leaf tissue of RNA-directed DNA methylation mutants
ORGANISM(S): Arabidopsis thaliana 
2012-05-26 | E-GEOD-36143 | biostudies-arrayexpress
TranscriptomicsGenome-wide connection between DNA methylation and DNA replication timing
DNA methylation and DNA replication timing were examined across a variety of human tissues and cell lines, applying microarray-based techniques. The analyses revealed that late-replicating DNA was demethylated compared to the methylation of early-replicating regions. DNA methylation: Epstein-Barr-Vi...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-24947 | biostudies-arrayexpress
GenomicsAn IDN2-containing complex involved in RNA-directed DNA methylation in Arabidopsis
This SuperSeries is composed of the following subset Series: GSE36129: An IDN2-containing complex involved in RNA-directed DNA methylation in Arabidopsis [leaves RNA-seq] GSE36143: An IDN2-containing complex involved in RNA-directed DNA methylation in Arabidopsis [BS-seq] GSE37206: An IDN2-containin...
ORGANISM(S): Arabidopsis thaliana 
2012-05-25 | E-GEOD-36148 | biostudies-arrayexpress
GenomicsDnmt2-dependent methylomes lack biologically relevant DNA methylation patterns [Schistosoma mansoni]
Dnmt2 is a widely conserved protein, which is closely related to eukaryotic DNA methyltransferases. However, Dnmt2 shows a robust tRNA methyltransferase activity and only limited activity towards DNA. Interestingly, a recent study has provided evidence for a biologically important function of Dnmt2-...
ORGANISM(S): Schistosoma mansoni 
2013-05-06 | E-GEOD-39997 | biostudies-arrayexpress
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