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GenomicsGenomic Study of RNA Polymerase II and III SNAPc-Bound Promoters Reveals a Gene Transcribed by both Enzymes and a Broad Use of Common Activators
SNAPc-dependent promoters are unique among cellular promoters in being very similar to each other, even though some of them recruit RNA polymerase II and other RNA polymerase III. We have examined all SNAPc-bound promoters present in the human genome. We find that there is a surprisingly small numbe...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-38303 | biostudies-arrayexpress
GenomicsThe SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription [Yeast cells]
The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-29 | E-GEOD-52997 | biostudies-arrayexpress
GenomicsFunctional association of Gdown1 with RNA Polymerase II in Human
Most human genes are loaded with promoter proximally paused RNA polymerase II (RNAP II) molecules that are poised for release into productive elongation by P-TEFb. Gdown1, a protein that renders RNAP II responsive to mediator, is involved in RNAP II elongation control. During in vitro transcription ...
ORGANISM(S): Homo sapiens 
2012-01-13 | E-GEOD-32442 | biostudies-arrayexpress
TranscriptomicsRNA polymerase II - Mediator interaction
Comparison of genome-wide RNA polymerase II occupancy in wild-type and rpb3-2 yeast strains
ORGANISM(S): Saccharomyces cerevisiae 
2011-10-26 | E-MEXP-3043 | biostudies-arrayexpress
GenomicsPolycomb Protein Ezh1 Promotes RNA Polymerase II Elongation
Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, Enhancer of Zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine-27 of histone H3 (...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-25549 | biostudies-arrayexpress
GenomicsRNA polymerase II pausing downstream of core histone genes is different from genes producing polyadenylated transcripts
Recent genome-wide chromatin immunoprecipitation coupled high throughput sequencing (ChIP-seq) analyses performed in various eukaryotic organisms, analysed RNA Polymerase II (Pol II) pausing around the transcription start sites of genes. In this study we have further investigated genome-wide binding...
ORGANISM(S): Homo sapiens 
2012-06-15 | E-GEOD-34001 | biostudies-arrayexpress
GenomicsPoised RNA Polymerase II changes over developmental time and prepares genes for future expression (ChIP-seq data)
Poised RNA polymerase II is predominantly found at developmental control genes and is thought to allow their rapid and synchronous induction in response to extracellular signals. How the recruitment of poised RNA Pol II is regulated during development is not known. By isolating muscle tissue from Dr...
ORGANISM(S): Drosophila melanogaster 
2012-12-20 | E-GEOD-34301 | biostudies-arrayexpress
TranscriptomicsGenome-wide control of RNA polymerase II activity by cohesin (sequencing)
Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest changes in cohesin function that do not disrupt ch...
ORGANISM(S): Drosophila melanogaster 
2013-04-24 | E-GEOD-42397 | biostudies-arrayexpress
ProteomicsStructure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex, and the Regulation of Transcription
MedPIC: Crosslinking-MS of 54 subunit pre-initiation complex from yeast. MedPolII: Crosslinking-MS of 33 subunit Mediator + polII complex from yeast.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2016-08-02 | MSV000080013 | MassIVE
GenomicsGlobal impact of RNA polymerase II elongation inhibition on alternative splicing regulation (ChIP-Seq)
The rate of RNA polymerase II (pol II) elongation can influence splice site selection in nascent transcripts, yet the extent and physiological relevance of this kinetic coupling between transcription and alternative splicing is not well understood. We performed experiments to perturb pol II elongati...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-25494 | biostudies-arrayexpress
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