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TranscriptomicsAn RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity
This SuperSeries is composed of the following subset Series: GSE11240: An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity, Experiment A GSE11241: An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Id...
ORGANISM(S): Mus musculus 
2008-07-11 | E-GEOD-11243 | biostudies-arrayexpress
TranscriptomicsAn RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity, Experiment B
Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We...
ORGANISM(S): Mus musculus 
2008-07-11 | E-GEOD-11241 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of mouse chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity, experiment A
Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11240 | biostudies-arrayexpress
TranscriptomicsRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukemia
Epigenetic pathways regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. While chromatin alterations are...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-29799 | biostudies-arrayexpress
GenomicsGenomewide T. brucei RNAi screen using proteasome inhibitor
Genomewide T. brucei RNAi screen using proteasome inhibitor
PRJEB31738 | ENA
GenomicsGenome-wide T. brucei RNAi screen with compound 25
Genome-wide T. brucei RNAi screen with compound 25
PRJEB38509 | ENA
TranscriptomicsAn RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation
Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor. The brain-infiltrative character of glioblastoma makes complete surgical removal of the tumor impossible and neither radiation nor current chemotherapy provide cure. Recent evidence shows that glioblastoma mu...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-27931 | biostudies-arrayexpress
TranscriptomicsThe Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification
From a forward genetic screen for C. elegans genes required for RNAi, we identified rde-10 and through proteomic analysis of RDE-10-interacting proteins, we identified a protein complex containing the new RNAi factor RDE-11, the known RNAi factors RSD-2 and ERGO-1, as well as other candidate RNAi fa...
ORGANISM(S): Caenorhabditis elegans 
2012-04-07 | E-GEOD-37083 | biostudies-arrayexpress
TranscriptomicsA Genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis
In animals, piRNAs, and their associated Piwi proteins, guard germ cell genomes against mobile genetic elements via an RNAi-like mechanism. In C. elegans, 21U-RNAs comprise the piRNA class and these collaborate with 22G RNAs, via unclear mechanisms, to discriminate self from non-self and selectively...
ORGANISM(S): Caenorhabditis elegans 
2014-04-01 | E-GEOD-53970 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates Fasudil as an anti-leukemic drug.
Acute myeloid leukemia (AML) is characterized by a marked genetic heterogeneity, which complicates the development of novel therapeutics. The delineation of pathways essential within the patient-individual mutational background might overcome this limitation and facilitate personalized treatment. We...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68925 | biostudies-arrayexpress
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