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ProteomicsRole of TbTim20 in mitochondrial protein import in trypanosomes – TbTim20 RNAi data
Protein import across the mitochondrial inner membrane typically depends on two protein translocases of the inner membrane (TIM) complexes and the membrane potential. The protozoan parasite Trypanosoma brucei, however, has a single, divergent TIM complex. Unlike other trypanosomal TIM subunits, TbTi...
ORGANISM(S): Trypanosoma brucei 
2025-10-27 | PXD061395 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome Rnai-induced gene depletion Label-free quantification Mitochondrial protein import 
TranscriptomicsRNAi of TbNMD3 in procyclic form Trypanosoma brucei lines
A procyclic form Trypansome brucei RNAi line (PTT parental line, transfected with pALC14 incorporating a TbNMD3 gene fragment) capable of inducing depletion of TbNMD3 was analysed for mRNA expression by RNAseq Cells were grown for 72 hours in culture; RNAi was induced in cells by the addition of 1 m...
ORGANISM(S): Trypanosoma brucei brucei 
2015-04-28 | E-GEOD-67246 | biostudies-arrayexpress
TranscriptomicsCharacterization of a P-REX1 gene signature in breast cancer cells
The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ErbB and other tyrosine-kinase receptors. Heregulin, a growth facto...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-77974 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of VSG in T. brucei for 1 or 3 days
As an additional strategy for investigating T. brucei transcriptome responsiveness, the mRNA of a highly important protein, the variant surface glycoprotein (VSG) the major surface protein in the bloodstream stage, was suppressed with RNAi. VSG RNAi results in arrest of cell cycle progression...
ORGANISM(S): Trypanosoma brucei 
2008-06-26 | E-MEXP-1528 | biostudies-arrayexpress
ProteomicsKnockdown of endocytosis-related proteins in Trypanosoma brucei
TbTOM1 is an ortholog of human TOM1, which was identified in Trypanosomes by bioinformatic approaches, and is potentially implicated in endocytosis. We wanted to further investigate TbTOM1 functions. Using a gene silencing approach we wanted to gain insights on possible effects on vesicle sorting an...
ORGANISM(S): Trypanosoma brucei 
2026-08-24 | PXD060385 | Pride
Trypanosoma Tom1 Gene silencing Endosome-sorting complex required for transport Endocytosis Rnai 
ProteomicsKnockdown of endocytosis-related proteins in Trypanosoma brucei (TbVPS23)
TbVPS23 is part of the ESCRT-I (endosome-sorting complex required for transport-I) complex in Trypanosoma brucei. Moreover, TbTOM1 is an ortholog of human TOM1, which was identified in Trypanosomes by bioinformatic approaches, and is potentially implicated in endocytosis. We wanted to further invest...
ORGANISM(S): Trypanosoma brucei 
2026-08-24 | PXD060396 | Pride
Trypanosoma Tom1 Vps23 Gene silencing Endosome-sorting complex required for transport Endocytosis Rnai 
GenomicsEffect of depletion of atp-2 by RNA interference on gene expression during the development of Caenorhabditis elegans
Effect of depletion of atp-2 by RNA interference on gene expression during the development of Caenorhabditis elegans
PRJNA1007561 | ENA
TranscriptomicsRNA-Seq of UPF1, SMG5 or SMG6 depletion in human embryonic kidney cell line HEK293 via the dTAG degron system and siRNA-mediated knockdowns
Nonsense-mediated decay (NMD) is a translation-coupled mechanism that targets mRNAs harboring a premature stop codon (PTC) for degradation, thereby serving as a quality control and gene regulatory pathway ensuring transcriptome integrity. UPF1 is the central NMD factor required for PTC recognition a...
ORGANISM(S): Homo sapiens 
2026-01-30 | E-MTAB-15521 | biostudies-arrayexpress
TranscriptomicsDepletion of histone deacetylase 3 antagonizes PI3K-mediated tissue overgrowth through the acetylation of histone H4 at lysine 16
Histone acetylation is one of the best studied gene modifications and has been shown to be involved in numerous important biological processes. HereinM-oM-
ORGANISM(S): Drosophila melanogaster 
2012-06-19 | E-GEOD-38552 | biostudies-arrayexpress
GenomicsEffect of the depletion of PuREBP1 (Tb927.4.4550) on the transcriptome of Trypanosoma brucei [RNAi]
Effect of the depletion of PuREBP1 (Tb927.4.4550) on the transcriptome of Trypanosoma brucei [RNAi]
PRJNA607264 | ENA
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