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TranscriptomicsRNase G complementation of rne null mutation identifies functional interrelationships with RNase E
The Escherichia coli endoribonucleases RNase E (Rne) and RNase G (Rng) have sequence similarity and broadly similar sequence specificity. Whereas the absence of Rne normally is lethal, we show here that E. coli bacteria that lack the rne gene can be made viable by overexpression of Rng. Rng-compleme...
ORGANISM(S): Escherichia coli 
2005-08-13 | E-GEOD-3123 | biostudies-arrayexpress
ProteomicsTargeting the translation machinery: The RNase Y specificity factor Y-complex coordinates ribosome degradation
Limiting the synthesis and activity of ribosomes is crucial for responding to various stresses, including nutrient starvation or proteotoxic stress. In Bacillus subtilis, this is achieved through the coordinated action of the alarmones (p)ppGpp and the transcription factor Spx. In this study, we per...
ORGANISM(S): Bacillus subtilis 
2026-04-09 | PXD065462 | Pride
Rnase y Ribosome Bacillus subtilis 
GenomicsMaturation of polycistronic mRNA by RNase Y and its associated Y-complex in Gram-positive bacteria
Maturation of polycistronic mRNA by RNase Y and its associated Y-complex in Gram-positive bacteria
PRJNA423050 | ENA
TranscriptomicsRNA processing in Bacillus subtilis: Identification of targets of the essential RNase Y
RNA processing and degradation is initiated by endonucleolytic cleavage of the target RNAs. In many bacteria, this activity is performed by RNase E which is not present in Bacillus subtilis and other Gram-positive bacteria. Recently, the essential endoribonuclease RNase Y has been discovered in B. s...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2011-08-31 | E-GEOD-30430 | biostudies-arrayexpress
GenomicsGenome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria
During transcription the nascent RNA can invade the DNA template, forming extended RNA-DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase H to map targets of RNase H activity throughout budding yeast genome. In wild-type strains, R-loops were readily detected over...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-03 | E-GEOD-53420 | biostudies-arrayexpress
OtherMaturation of polycistronic mRNA by RNase Y and its associated Y-complex in Gram-positive bacteria
Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability and discordant abundance among co-transcribed genes. RNase Y, the major endonuclease for mRNA decay in Bacillus subtilis, was originally identified for its cleavage activity towards the cggR-gapA operon, an event ...
ORGANISM(S): Bacillus subtilis Staphylococcus aureus 
2018-05-12 | GSE108295 | GEO
TranscriptomicsRNA processing in Bacillus subtilis: Identification of targets of the essential RNase Y
RNA processing and degradation is initiated by endonucleolytic cleavage of the target RNAs. In many bacteria, this activity is performed by RNase E which is not present in Bacillus subtilis and other Gram-positive bacteria. Recently, the essential endoribonuclease RNase Y has been discovered in B. s...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2011-09-01 | GSE30430 | GEO
TranscriptomicsBacillus subtilis Rnase Y activity in vivo analysed by tiling microarrays
RNase Y is an essential endoribonuclease affecting global mRNA stability in Bacillus subtilis. We used high-resolution tiling arrays to analyze the effect of RNase Y depletion on RNA abundance covering the entire genome. The data confirm that this endoribonuclease plays a key role in initiating the ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2013-01-15 | E-GEOD-38897 | biostudies-arrayexpress
GenomicsInvestigation of the regulon and RNA targets of RNase Y in Campylobacter jejuni
Investigation of the regulon and RNA targets of RNase Y in Campylobacter jejuni
PRJNA962809 | ENA
TranscriptomicsRNase Y of Staphylococcus aureus and its role in the activation of virulence genes
RNase Y of Bacillus subtilis is a key member of the degradosome and important for bulk mRNA turnover. In contrast to B. subtilis, the RNase Y homologue (rny/cvfA) of Staphylococcus aureus is not essential for growth. Here we found that RNase Y plays a major role in virulence gene regulation. Accordi...
ORGANISM(S): Staphylococcus aureus 
2012-06-21 | GSE34980 | GEO
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