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ProteomicsRNF114 Co-IP experiments to identify binding partners
To identify the substrates of RNF114 in the context of PARylation-mediated DDR, we performed an IP-MS (immunoprecipitation coupled with MS) experiment, using cells treated with either H2O2 or H2O2+Talazoparib. We identified a large number of PARP1 peptides from the RNF114 immunoprecipitants only in ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045231 | Pride
Rnf114 chromatin parp1 
ProteomicsTMT-based proteomics analysis of proteome changes in RNF114-/- mouse oocytes
The proteome changes were quantified in RNF114-/- mouse oocyte using TMT 6-plex by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2021-06-16 | PXD023458 | Pride
Proteomics Tmt Mouse Oocyte 
TranscriptomicsMaternal RNF114 plays critical roles in activation of the early zygotic genome through promoting ubiquitin-mediated degradation of Chromobox protein CBX5
Zygotic genomic activation (ZGA) is a landmark event in the maternal-to-zygotic transition (MZT), and the regulation of ZGA by maternal factors remains to be elucidated. In this study, the depletion of maternal RNF114 led to 2-cell embryos developmental arrest in mice. RNF114 was proven to play an i...
ORGANISM(S): Mus musculus 
2021-06-16 | GSE164532 | GEO
GenomicsMaternal RNF114 plays critical roles in activation of the early zygotic genome through promoting ubiquitin-mediated degradation of Chromobox protein CBX5
Maternal RNF114 plays critical roles in activation of the early zygotic genome through promoting ubiquitin-mediated degradation of Chromobox protein CBX5
PRJNA691066 | ENA
UnknownRNF114 Interacts with EWSR1 to Regulate VEGFR2 in HER2-positive Breast Cancer.
Not available
S-EPMC11905403 | biostudies-literature
UnknownIdentification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose.
Not available
S-EPMC12241653 | biostudies-literature
ProteomicsIdentification of RNF114 as ADPrUb reader through chemical synthesis of non-hydrolysable Ubiquitylated ADPribose
Ubiquitination is a much-studied post-translational modification (PTM) playing crucial roles in regulating cellular processes across eukaryotes. Canonical ubiquitination relies on a cascade of E1-, E2-, and E3 enzymes which conjugate the Gly76 C-terminus of ubiquitin (Ub) to the lysine side chains i...
ORGANISM(S): Homo sapiens (Human) 
2025-06-20 | PXD058087 | Pride
Rnf114 Chemoproteomics Adp-ribosylation Ubiquitin 
UnknownThe E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition.
Not available
S-EPMC5286393 | biostudies-literature
UnknownRNF114 and RNF166 exemplify reader-writer E3 ligases that extend K11 polyubiquitin onto sites of MARUbylation.
Not available
S-EPMC12583694 | biostudies-literature
UnknownNimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer.
Not available
S-EPMC10599614 | biostudies-literature
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