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ProteomicsRNF212B E3 ligase is essential for crossing over maturation and mouse fertility
Meiosis, a reductional cell division, relies on precise initiation, maturation and resolution of crossovers (COs)-connections between homologs chromosomes-to ensure their accurate segregation during metaphase I. This process is finely regulated in eukaryotes by the interplay of RING-E3 ligases such ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-31 | PXD047019 | Pride
Crossing-over Ubiquitylation Meiotic recombination Chiasma Fertility Sumoylation Rnf212b Ring e3 ligases Spermatogenesis 
UnknownRNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse.
Not available
S-EPMC11194559 | biostudies-literature
UnknownA pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure.
Not available
S-EPMC10133878 | biostudies-literature
ProteomicsRNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse
Meiosis, a reductional cell division, relies on precise initiation, maturation and resolution of crossovers (COs) during prophase I to ensure the accurate segregation of homologous chromosomes during metaphase I. This process is regulated by the interplay of RING-E3 ligases such as RNF212 and HEI10 ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD050239 | Pride
Meiosis Ubiquitin 
ProteomicsRNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse
Meiosis, a reductional cell division, relies on precise initiation, maturation and resolution of crossovers (COs) during prophase I to ensure the accurate segregation of homologous chromosomes during metaphase I. This process is regulated by the interplay of RING-E3 ligases such as RNF212 and HEI10 ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD047332 | Pride
Meiosis Sumo Ubiquitin 
UnknownCoding and noncoding variants in HFM1, MLH3, MSH4, MSH5, RNF212, and RNF212B affect recombination rate in cattle.
Not available
S-EPMC5052053 | biostudies-literature
UnknownA Genomic Region Containing REC8 and RNF212B Is Associated with Individual Recombination Rate Variation in a Wild Population of Red Deer (Cervus elaphus).
Not available
S-EPMC6027875 | biostudies-literature
UnknownDistinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis.
Not available
S-EPMC11745341 | biostudies-literature
UnknownHEIP1 orchestrates pro-crossover protein activity during mammalian meiosis.
Not available
S-EPMC12407729 | biostudies-literature
UnknownHEIP1 orchestrates pro-crossover protein activity during mammalian meiosis.
Not available
S-EPMC12582315 | biostudies-literature
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