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TranscriptomicsMicroarray analysis of purified germ cells in mouse
Microarray analysis of purified pachytene spermatocytes and round spermatids. Each stage was examined in wild type and RNF8 knockout mice in two biological replicates. We performed microarray analysis using Affymetrix Gene 1.0 ST Arrays with purified pachytene spermatocytes and round spermatids. Pac...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-39302 | biostudies-arrayexpress
ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
ProteomicsRNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling
RNF8 is a key E3 ubiquitin ligase functioning in both DSB- and UV-induced DDR, identification of additional substrates will help further elucidate its role in DNA damage signaling. To identify substrates of ubiquitin ligases, we have recently devised a method based on proximity-dependent biotin labe...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD006156 | Pride
Substrate identification Rnf8 Dna damage E3 ligase 
GenomicsGlioblastoma stem cells after RNF8 overexpression
Glioblastoma stem cells after RNF8 overexpression
PRJNA787899 | ENA
TranscriptomicsGlioblastoma stem cells after RNF8 overexpression
RNF8 is downregulated in glioblastoma and low RNF8 expression correlates with poor patient prognosis. Overexpression (OE) of RNF8 in glioblastoma stem cell (GSC) impairs its proliferation and tumorigenicity, and the anti-cancer effects of RNF8 are dependent on both its FHA and RING domains. Paradoxi...
ORGANISM(S): Homo sapiens 
2022-12-10 | GSE190638 | GEO
TranscriptomicsRnf8 loss promotes breast carcinogenesis
Coordination of signaling pathways is essential for tissue homeostasis and for preventing cancer development. Here, we show that the E3 ligase Rnf8, an important component of the DNA double-strand break (DSB) signaling, is critical for cell-fate commitment of the mammary epithelial progenitors. Furt...
ORGANISM(S): Mus musculus 
2017-01-01 | GSE76075 | GEO
GenomicsRNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
PRJNA837125 | ENA
GenomicsMus musculus
Rnf8 loss promotes breast carcinogenesis
PRJNA306167 | ENA
GenomicsRNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies, including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant cancers, we sought to identify novel targets to selectively kill these cancers. Here, we report that loss of RNF8 signif...
ORGANISM(S): Homo sapiens 
2023-09-14 | GSE202723 | GEO
UnknownRNF8 deficiency results in neurodegeneration in mice.
Not available
S-EPMC4851709 | biostudies-literature
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