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MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
ProteomicsProteomic Analysis of fly brain cytoplasmic RNP granules containing the lncRNA mimi
In neurons, mRNAs and associated RNA-binding proteins assemble into ribonucleoprotein (RNP) granules essential to regulate mRNA trafficking, local translation, and turnover. Dysregulation of RNA-protein condensation can disturb synaptic plasticity. We report that the novel lncRNA mimi is a constitut...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-12 | PXD034453 | Pride
Rnp granules  fly brain  neurons  lncrna mimi Fne  rbp9 Drosophila  relative ibaq  quantitative proteomics 
UnknownTyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain.
Not available
S-EPMC8064753 | biostudies-literature
GenomicsRNP granule enrichment from Trypanosoma brucei
Novel insights into RNP granules by employing the trypanosome’s microtubule skeleton as a molecular sieve
PRJEB8187 | ENA
UnknownIntrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly.
Not available
S-EPMC5824733 | biostudies-literature
TranscriptomicsProteomic and transcriptomic analyses of Dhh1 complexes reveals mitochondrial RNP complex association with yeast P-bodies
P-bodies (PB) are cytoplasmic RNP complexes that aggregate into foci when cells are exposed to stress. While the core components and stress response of PB and related RNP granules are conserved, it remains unclear how and why cells assemble mRNP complexes into granule foci during stress. We use mas...
ORGANISM(S): Saccharomyces cerevisiae 
2015-09-16 | E-GEOD-65989 | biostudies-arrayexpress
UnknownALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.
Not available
S-EPMC4660210 | biostudies-literature
TranscriptomicsRNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome
Ribonucleoprotein (RNP) granules are non-membrane bound organelles thought to assemble by protein-protein interactions of RNA-binding proteins. We present evidence that a wide variety of RNAs self-assemble in vitro into either liquid-liquid phase separations or more stable assembles, referred to as ...
ORGANISM(S): Saccharomyces cerevisiae 
2017-05-23 | GSE99170 | GEO
ProteomicsContext-dependent and disease-specific diversity in stress granules formed from preexisting protein interactions
Affinity-capture proteomics studies using endogenously tagged G3BP1 with APEX2 to capture the stress granule proteome at steady state and upon stress induction. This was done in 293T cells as well as induced pluripotent stem cells differentiated into neuronal progenitor cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081554 | MassIVE
UnknownMulticolour single-molecule tracking of mRNA interactions with RNP granules.
Not available
S-EPMC6375083 | biostudies-literature
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