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TranscriptomicsRo60-knockout cells
RNA-seq of Ro60-null GM12878 cell lines in order to determine the gene expression changes resulting from loss of Ro60. 3 separate clones of Ro60(Trove2)-null cells derived from zinc finger nuclease targeting of exon 2, two wildtype biological replicates, +/- IFNa for 6 hours.
ORGANISM(S): Homo sapiens 
2015-09-16 | E-GEOD-72501 | biostudies-arrayexpress
TranscriptomicsRo60 iCLIP
Autoantibodies target the RNA-binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren's syndrome. However, whether Ro60 and its associated RNAs contribute to disease pathogenesis is unclear. We catalogued the Ro60-associated RNAs in human cell lines. iCLIP in 2 cell lines (GM12878, K5...
ORGANISM(S): Homo sapiens 
2015-09-16 | E-GEOD-72500 | biostudies-arrayexpress
TranscriptomicsRo60 iCLIP
Autoantibodies target the RNA-binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren's syndrome. However, whether Ro60 and its associated RNAs contribute to disease pathogenesis is unclear. We catalogued the Ro60-associated RNAs in human cell lines.
ORGANISM(S): Homo sapiens 
2015-09-16 | GSE72500 | GEO
TranscriptomicsRo60-knockout cells
RNA-seq of Ro60-null GM12878 cell lines in order to determine the gene expression changes resulting from loss of Ro60.
ORGANISM(S): Homo sapiens 
2015-09-16 | GSE72501 | GEO
GenomicsCommensal Orthologs of the Human Autoantigen Ro60 as Triggers of Autoimmunity in Lupus
Commensal Orthologs of the Human Autoantigen Ro60 as Triggers of Autoimmunity in Lupus
PRJEB24742 | ENA
ProteomicsValidation of the anti-Ro60 antibody (sc-100844, Sants Cruz Biotechnology, Inc) by coimmunoprecipitation from total HEK293 cell lysates
The mouse monoclonal anti-Ro60 antibody (sc-100844, Sants Cruz Biotechnology, Inc) has been validated by coimmunoprecipitation from total Flp-In T-REx 293 cell lysates. An anti-His antibody (SAB1305538, Sigma-Aldrich) was used as a negative control (see experimental details in Jeandard et al., "CoLo...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD037383 | Pride
Ro60 Antibody Trove2 Sc-100844 Coloc-seq 
GenomicsHomo sapiens
Ro60 iCLIP
PRJNA294175 | ENA
TranscriptomicsDefective structural RNA processing in relapsing-remitting multiple sclerosis
It is fundamentally unknown how normal cellular processes or responses to extracellular stimuli may invoke polyadenylation and degradation of ncRNA substrates or if human disease processes exhibit defects in polyadenylation of ncRNA substrates as part of their pathogenesis. Our results demonstrate t...
ORGANISM(S): Homo sapiens 
2015-03-10 | E-GEOD-66573 | biostudies-arrayexpress
GenomicsHomo sapiens
Ro60-knockout cells
PRJNA294174 | ENA
UnknownRo60 and Y RNAs: structure, functions, and roles in autoimmunity.
Not available
S-EPMC6542706 | biostudies-literature
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