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TranscriptomicsExpression data of pachytene spermatocytes and round spermatids from young and aged Brown Norway rats
Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression. A full genome microarray was used to determine if distinct pathways of genes were altered in expression in germ cells (pachytene spermatocytes or roun...
ORGANISM(S): Rattus norvegicus 
2012-01-06 | E-GEOD-29963 | biostudies-arrayexpress
TranscriptomicsExpression data of CD9 positive germ cells from young and aged Sprague Dawley germ cell specific GFP rats
Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression in the spermatogonial cells at the foundation of spermatogenesis A full genome microarray was used to determine if distinct pathways of genes were alte...
ORGANISM(S): Rattus norvegicus 
2013-12-05 | E-GEOD-50143 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of eight-cell stage rat embryos sired by paternally exposed males to saline or BEP
8-cell stage rat embryos were sired by males treated with saline or a chemotherapeutic cocktail, BEP, consisting of Bleomycin, Etoposide, and Cisplatin for 9 weeks. Animals were given an additional 9 weeks of recovery, without any treatment, prior to mating. qPCR gene expression profiling for 84 ste...
ORGANISM(S): Rattus norvegicus 
2014-03-13 | E-GEOD-55842 | biostudies-arrayexpress
TranscriptomicsAge-dependent Response of Isolated Male Germ Cells to Oxidative Stress
Male germ cells from young and aged Rats were Isolated and cultured and then treated with pro-oxidant SIN-1 and antioxidant EUK134 Study of the response of isolated male germ cells from young and aged Brown Norway Rats to oxidative stress. Treatment of Isolated and cultured germ cells with pro-oxida...
ORGANISM(S): Rattus norvegicus 
2015-04-30 | E-GEOD-66976 | biostudies-arrayexpress
TranscriptomicsToxicogenomic Screen of Replacements for bis(2-ethylhexyl) phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line
Phthalate plasticizers are being phased out of consumer products because of their endocrine disrupting properties. This has resulted in a need to find safe alternatives that can plasticize polyvinyl chloride (PVC) while being inexpensive and biodegradable. We aim to study the toxicogenomic profile o...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-66812 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis of Postnatal Day 6 Testes Sired by Paternally Exposed Males to Saline or BEP
To determine the changes in gene expression of testes from postnatal day 6 pups, a window in development where spermatogonial stem cells is predominant, following paternal exposure to saline or BEP, a chemotherapeutic coktail used to treat testicular cancer Postnatal day 6 testes (2) of pups sired b...
ORGANISM(S): Rattus norvegicus 
2013-05-15 | E-GEOD-46910 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in male rat germ cells after chronic cyclophosphamide treatment
To further understand the effects of chronic cyclophosphamide treatment on spermatogenesis, we used whole genome microarrays to identify differentially expressed genes in pachytene spermatocytes and round spermatids from treated and control male rats. Pachytene spermatocytes and round spermatids fro...
ORGANISM(S): Rattus norvegicus 
2016-03-23 | E-GEOD-79471 | biostudies-arrayexpress
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