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TranscriptomicsDSIF and RNA polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes
Histone deacetylase Rpd3 is part of two distinct complexes: the large (Rpd3L) and small (Rpd3S) complexes. While Rpd3L targets specific promoters for gene repression, Rpd3S is recruited to ORFs to deacetylate histones in the wake of RNA polymerase II, to prevent cryptic initiation within genes. Meth...
ORGANISM(S): Saccharomyces cerevisiae 
2010-11-28 | E-GEOD-22636 | biostudies-arrayexpress
UnknownVestibular impact of Friedreich ataxia in early onset patients.
Not available
S-EPMC7254732 | biostudies-literature
TranscriptomicsKin28 Regulates the Transient Association of Mediator with Core Promoters
Mediator is an essential, broadly utilized eukaryotic transcriptional co-activator. How and what it communicates from activators to RNA polymerase II remains an open question. Here we performed genome-wide location profiling of yeast Mediator subunits. Mediator is not found at core promoters but rat...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-24 | E-GEOD-55402 | biostudies-arrayexpress
TranscriptomicsControl of chromatin structure by Spt6 has different consequences in coding and regulatory regions
Spt6 is a highly conserved factor that carries out important functions in transcription and chromatin structure. To gain new insights into Spt6, we measured nucleosome occupancy along Saccharomyces cerevisiae chromosome III in an spt6 mutant and found that the level of nucleosomes is greatly reduced...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-01 | E-GEOD-21787 | biostudies-arrayexpress
TranscriptomicsA Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays Between Kinase, Phosphatase and Isomerase Enzymes Along Genes
Transcription by RNA polymerase II (RNAPII) is coupled to mRNA processing and chromatin modifications via the C-terminal domain (CTD) of its largest subunit, consisting of multiple repeats of the heptapeptide YSPTSPS. Pioneering studies showed that CTD serines are differentially phosphorylated along...
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-01 | E-GEOD-29403 | biostudies-arrayexpress
TranscriptomicsFACT and Spt6 Prevent Cryptic Transcription by Impeding H2A.Z Loading in Gene Bodies
H2A.Z is a highly conserved histone variant involved in several key nuclear processes. It is incorporated into promoters by SWR-C-related chromatin remodeling complexes, but whether it is also actively excluded from non-promoter regions is not clear. Here, we provide genomic and biochemical evidence...
ORGANISM(S): Saccharomyces cerevisiae 
2015-05-12 | E-GEOD-62880 | biostudies-arrayexpress
UnknownEfficacy and Safety of Osilodrostat in Paraneoplastic Cushing Syndrome: A Real-World Multicenter Study in France.
Not available
S-EPMC10188310 | biostudies-literature
TranscriptomicsChIP-chip of histone variants and modifications in S. pombe WT and various mutants
ChIP-chip of histone variants and modifications in A. thaliana WT and various mutants In Schizosaccharomyces pombe, H2AZ, H3, H3 acetylated, H3K36me3, H3K4me3 as well as RNAPII (along with associated DNA sequences) were immunoprecipitated. The ChIPs were performed in duplicate from WT cells as well ...
ORGANISM(S): Schizosaccharomyces pombe 
2012-12-01 | E-GEOD-31071 | biostudies-arrayexpress
TranscriptomicsA positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B mono-ubiquitylation to regulate transcript elongation in fission yeast
Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification within transcribed regions, but it remains uncertain how these modifications influence, or are influenced by, properties of the elongation complex. Here we establish an intimate link betw...
ORGANISM(S): Schizosaccharomyces pombe 
2012-12-01 | E-GEOD-31070 | biostudies-arrayexpress
UnknownCirculating Tumor Cells and Circulating Tumor DNA Detection in Potentially Resectable Metastatic Colorectal Cancer: A Prospective Ancillary Study to the Unicancer Prodige-14 Trial.
Not available
S-EPMC6627974 | biostudies-literature
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