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ProteomicsPediatric COVID-19 Human plasma LC-MS
Analysis of plasma from adult and pediatric COVID-19 patients via untargeted and targeted proteomics reveals activation in complement and coagulation pathways as common elements in both populations
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD040437 | Pride
Plasma Covid Childern Lc-ms 
ProteomicsCovid Human plasma LC-MS Multiplatform Analyses Reveal Distinct Drivers of Systemic Pathogenesis in Adult Versus Pediatric Severe Acute COVID-19
The adult data set. The pathogenesis of multi-organ dysfunction associated with severe acute SARS-CoV-2 infection remains poorly understood. Endothelial damage and microvascular thrombosis have been identified as drivers of COVID-19 severity, yet the mechanisms underlying these processes remain elus...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD040438 | Pride
Human Lc-ms Covid Plasma 
ProteomicsQuantification of Alpha synuclein in erythrocytes
Idiopathic Parkinson’s disease (iPD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). Mutations in the SCNA gene, which encodes the protein alpha synuclein (α-syn), are associated with familial forms of Parkinson's disease (PD). Additionally, Lewy bodies (LBs) rich...
ORGANISM(S): Homo Sapiens 
2026-06-12 | PXD058953 | panorama
ProteomicsMulti-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease
Simultaneous extraction of proteins and lipids from human frontal cortex and cerebellum brain tissue was performed using the MPLEx procedure for both control and Alzheimer's disease patients. The isolated proteins were then reduced, alkylated, tryptically digested and evaluated with LC-IMS-MS. The p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-08 | MSV000092627 | MassIVE
MetabolomicsGNPS - Multi-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease
Simultaneous extraction of proteins and lipids from human frontal cortex and cerebellum brain tissue was performed using the MPLEx procedure for both control and Alzheimer's disease patients. The isolated proteins were then reduced, alkylated, tryptically digested and evaluated with LC-IMS-MS. The p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-08 | MSV000092627 | GNPS
UnknownEffects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy.
Not available
S-EPMC3333485 | biostudies-literature
UnknownEffect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.
Not available
S-EPMC4123233 | biostudies-literature
UnknownLong-term effects of intensive glucose lowering on cardiovascular outcomes.
Not available
S-EPMC4083508 | biostudies-literature
UnknownEffects of intensive glucose lowering in type 2 diabetes.
Not available
S-EPMC4551392 | biostudies-literature
UnknownEffects of combination lipid therapy in type 2 diabetes mellitus.
Not available
S-EPMC2879499 | biostudies-literature
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