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TranscriptomicsGenome-wide replication analysis of a yeast eco1 mutant by deep sequencing.
Eco1 is the acetyltransferase that establishes sister-chromatid cohesion during DNA replication. Budding yeast with an eco1 mutation that genocopies Roberts syndrome displaysreduced ribosomal DNA (rDNA) transcription and a transcriptional signature of starvation. Weshow that deleting FOB1, a gene en...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54742 | biostudies-arrayexpress
TranscriptomicsThe cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54743 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis comparing yeast Eco1 mutant W216G to mutants of FOB1 and RAD61
Eco1 is an acetyltransferase subunit of the cohesin complex and acts during DNA replication to establish cohesion between sister chromatids. However, cohesin has additional functions in gene expression, DNA damage repair, and higher-order organization of chromosomes. The eco1 mutant W216G disrupts a...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54741 | biostudies-arrayexpress
UnknownControlled Substance Lock-In Programs: Examining An Unintended Consequence Of A Prescription Drug Abuse Policy.
Not available
S-EPMC7262687 | biostudies-literature
UnknownChronic rheumatic heart disease with recrudescence of acute rheumatic fever on histology: a case report.
Not available
S-EPMC9295691 | biostudies-literature
TranscriptomicsA comparative systems analysis of polysaccharide-elicited responses in Neurospora crassa reveals carbon source-specific cellular adaptations
Filamentous fungi are powerful producers of hydrolytic enzymes for the deconstruction of plant cell wall polysaccharides. However, the central question of how these sugars are perceived in the context of the complex cell wall matrix remains largely elusive. To address this question in a systematic f...
ORGANISM(S): Neurospora crassa OR74A 
2013-11-27 | E-GEOD-42692 | biostudies-arrayexpress
UnknownStructural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders.
Not available
S-EPMC7981260 | biostudies-literature
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
TranscriptomicsGene Expression Profiling in the Lungs of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer
COPD is a common and disabling lung disease for which very few therapeutic options are currently available. We reasoned that global gene expression profiling of COPD lungs could reveal previously unidentified disease pathways for potential therapeutic interventions. Forty-eight human lung samples we...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8500 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of the newly described centipede Eupolybothrus cavernicolus sp.n.
We compiled the transcriptome by extracting mRNA, reverse transcription and Illumina sequencing, followed by assembly and annotation by comparison with public databases (including; Nr, SwissProt and COG). Quantitative data on the transcription abundance of each putative protein sequence is provided ...
ORGANISM(S): Eupolybothrus sp. PS-2013 
2013-10-28 | E-MTAB-1859 | biostudies-arrayexpress
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