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UnknownMolecular dynamics simulations of Hsp40 J-domain mutants identifies disruption of the critical HPD-motif as the key factor for impaired curing in vivo of the yeast prion [URE3].
Not available
S-EPMC6312664 | biostudies-literature
UnknownMapping of a single locus capable of complementing the defective heterochromatin phenotype of Roberts syndrome cells.
Not available
S-EPMC1226185 | biostudies-literature
MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsRibose utilization by the human commensal Bifidobacterium breve UCC2003
Growth of B. breve UCC2003 on ribose leads to the transcriptional induction of the rbsACBDK gene cluster. Generation and phenotypic analysis of an rbsA insertion mutant established that the rbs gene cluster is essential for ribose utilization, and that its transcription is likely regulated by a LacI...
ORGANISM(S): Bifidobacterium breve UCC2003 
2010-05-19 | E-GEOD-17325 | biostudies-arrayexpress
UnknownSite-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants.
Not available
S-EPMC4799508 | biostudies-literature
UnknownData for crystallisation, dissolution and saturation temperatures of a model fuel comprising eicosane crystallising from supersaturated toluene solutions in the presence of a cold-flow improver additive.
Not available
S-EPMC9309423 | biostudies-literature
UnknownMutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.
Not available
S-EPMC2856273 | biostudies-literature
TranscriptomicsExpression data from zebrafish depleted of Esco2
Our study in zebrafish is the first to use an animal model to understand the biology of the developmental disorder Roberts Syndrome (RBS). RBS is caused by mutations in the ESCO2 gene. We have used morpholinos (MO) to knock down esco2 in zebrafish to better understand the pathology of this rare huma...
ORGANISM(S): Danio rerio 
2011-03-01 | E-GEOD-27569 | biostudies-arrayexpress
UnknownIndividual- and area-level socioeconomic inequalities in diabetes mellitus in Saskatchewan between 2007 and 2012: a cross-sectional analysis.
Not available
S-EPMC6342700 | biostudies-literature
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