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TranscriptomicsAstrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis
Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve ad...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress
ProteomicsA cell competition-based drug screen identifies a novel compound that induces dual c-Myc degradation and p53 activation
BCR-Abl is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells. Leukemic stem cells are cancer-initiating cells that comp...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-07 | PXD018812 | Pride
Leukemia C-myc Drug screening Anticancer drug Abl tyrosine kinase Phosphoproteomics Mrna P53 
TranscriptomicsC. elegans embryos: control vs. mes-2 mutant
Transcriptional profiling of early C. elegans embryos comparing control (N2) embryos with mes-2 mutant embryos at different developmental stages: 2E (24-40 cells), 4E (50-90 cells) and 8E stage (100-200 cells). Goal was to determine the effects of mes-2 loss on global gene expression as embryos tran...
ORGANISM(S): Caenorhabditis elegans 
2010-05-18 | E-GEOD-14913 | biostudies-arrayexpress
UnknownMost cancers carry a substantial deleterious load due to Hill-Robertson interference.
Not available
S-EPMC9499534 | biostudies-literature
UnknownUncertain impacts on economic growth when stabilizing global temperatures at 1.5°C or 2°C warming.
Not available
S-EPMC5897830 | biostudies-literature
ProteomicsGFAP and MBP peptides in Traumatic Brain Injury
Glial fibrillary acidic protein (GFAP) is the major intermediate filament III protein of astroglia cells and is upregulated in astrogliosis following traumatic brain injury (TBI). Here we reported that GFAP is truncated at both the C- and N-terminals by cytosolic protease calpain to GFAP breakdown p...
ORGANISM(S): Homo Sapiens 
2022-07-18 | PXD026550 | panorama
UnknownSystemic effects of whole-body cooling to 35 °C, 33.5 °C, and 30 °C in a piglet model of perinatal asphyxia: implications for therapeutic hypothermia.
Not available
S-EPMC4241373 | biostudies-literature
GenomicsInterferon drives hepatitis C virus scarring of the epigenome and creates targetable vulnerabilities following viral clearance [array]
Interferon drives hepatitis C virus scarring of the epigenome and creates targetable vulnerabilities following viral clearance [array]
PRJNA706413 | ENA
UnknownImaging the Dynamics of the Electron Ionization of C2F6.
Not available
S-EPMC9574930 | biostudies-literature
UnknownNMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation.
Not available
S-EPMC3906135 | biostudies-literature
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