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Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 

BACKGROUND & AIMS: The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients...

2023-11-16 | MTBLS300 | MetaboLights
Identifying modes of resistance to a new experimental drug for a patient resistant to other therapies
We have analyzed and compared the post-translational modifications in the pathological tau proteins prepared from a wide range of tauopathies.
ORGANISM(S): Homo Sapiens (human) 
Comparison of pre and post metamorphis phases of cane toad Keywords: Developmental Stages Samples were harvested at 9, 18, 28 (pre-metamorph), 30 and 53 (post-metamorph) days of age and RNA extracted using Trizol Reagent (Invitrogen). Total RNA (100 mg) was reverse transcribed (Qiagen) and labelled ...
ORGANISM(S): Bufo marinus 
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