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TranscriptomicsThe gene encoding the hematopoietic stem cell regulator CCN3 (NOV) is under direct cytokine control through the transcription factors STAT5a/b.
Cytokines control the biology of hematopoietic stem and progenitor cells in part through the transcription factors STAT5a/b. CCN3/NOV has been reported as a positive regulator of hematopoietic stem and progenitor cells. We report microarray analyses of Lineage- Sca-1+ c-Kit+ (KSL) cells in the pre...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20684 | biostudies-arrayexpress
TranscriptomicsThe transcription factors STAT5a/b negatively regulate cell proliferation through the activation of cdkn2b and cdkn1a expression
Although the cytokine-inducible transcription factors STAT5a/b promote proliferation of a wide range of cell types, there are cell- and context specific cases in which loss of STAT5a/b results in enhanced cell proliferation. Here we report that loss of STAT5a/b from mouse embryonic fibroblasts (MEFs...
ORGANISM(S): Mus musculus 
2010-11-15 | E-GEOD-21861 | biostudies-arrayexpress
TranscriptomicsComparative Transcriptomics of Soybean Near Isogenic Lines in Response to Phytophthora Sojae
Phytophthora root and stem rot (PRR) of soybean, caused by Phytophthora sojae, is effectively controlled by Rps genes in soybean. Rps genes are race-specific, yet the mechanism of resistance, as well as susceptibility, remains largely unclear. Taking advantage of RNA-seq technology, we sequenced the...
ORGANISM(S): Glycine max 
2014-04-16 | E-GEOD-48524 | biostudies-arrayexpress
TranscriptomicsMultiple tissue transcriptomic responses to Piscirickettsia salmonis in Atlantic salmon (Salmo salar)
This experiment was aimed at understanding the early transcriptional response to the salmon pathogen Piscirikettsia salmonis at 48h post infection in multiple tissues. Agilent-based microarray platform with 4 44 K probes per slide (Salar_2; Agilent Design ID:025520) oligo microarray was used in thi...
ORGANISM(S): Salmo salar 
2012-05-01 | E-MTAB-685 | biostudies-arrayexpress
TranscriptomicsSusceptibilities of Atlantic salmon to Piscirickettsia salmonis
The aquaculture industry has confronted severe economic losses due to infectious diseases in the last years. Piscirickettsiosis or Salmonid Rickettsial Septicaemia (SRS) is the bacterial disease caused by Piscirickettsia salmonis. This Gram-negative, non-motile, cellular pathogen has the ability to ...
ORGANISM(S): Salmo salar 
2013-01-04 | E-GEOD-43255 | biostudies-arrayexpress
TranscriptomicsNeural embryonic stem cell (ESTn) test dose-responses of six compounds.
Effects of six compounds on stem cell neural development.
ORGANISM(S): Mus musculus 
2012-11-08 | E-TABM-1216 | biostudies-arrayexpress
TranscriptomicsThe molecular basis and evolution of cooperative brood care in bumblebees
Sibling care is a hallmark of the social insects, but its evolution remains challenging to explain. The hypothesis that sibling care evolved from ancestral maternal care in the primitively eusocial insects has been elaborated to involve heterochronic changes in gene expression. This elaboration lead...
ORGANISM(S): Bombus terrestris 
2014-06-01 | E-MTAB-2621 | biostudies-arrayexpress
UnknownVandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial.
Not available
S-EPMC3675689 | biostudies-literature
TranscriptomicsMyc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [Reprogramming_RNASEQ]
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic regulators modulate this process and contribute ...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-67715 | biostudies-arrayexpress
TranscriptomicsCultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (methylation)
The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension and sub-optimal vitamin D levels influence placental function and both are associated with preeclampsia, a condition associated wit...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-41336 | biostudies-arrayexpress
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