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TranscriptomicsCultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (methylation)
The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension and sub-optimal vitamin D levels influence placental function and both are associated with preeclampsia, a condition associated wit...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-41336 | biostudies-arrayexpress
TranscriptomicsCultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-41341 | biostudies-arrayexpress
TranscriptomicsCultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (expression)
The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension and sub-optimal vitamin D levels influence placental function and both are associated with preeclampsia, a condition associated wit...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-41331 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Previously we have shown that extravillous cytotrophoblast (EVT) outgrowth and migration on a collagen gel explant model were restricted by exposure to decidual natural killer cells (dNK). This study investigates the molecular causes behind this phenomenon. Genome wide DNA methylation of exposed and...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-60885 | biostudies-arrayexpress
TranscriptomicsThe Human Placental Methylome across gestational ages for chromosome 21
Tissue specific DNA methylation is present across many genomic elements, including large genomic regions. Most human tissues posses highly methylated genomes (>70%), but recent data has suggested the presence of partially methylated domains (PMDs) in some cell-lines. Placenta is a unique human tissu...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-MTAB-1508 | biostudies-arrayexpress
UnknownStable Boron Dithiolene Radicals.
Not available
S-EPMC7679077 | biostudies-literature
TranscriptomicsOverlapping DNA methylation profile between placentas with trisomy 16 and early-onset preeclampsia
Preeclampsia is one of the leading causes of maternal death worldwide. While the root cause is still unknown, the underlying biology of the disorder is becoming more clear. We recently published a study showing large, significant differences in DNA methylation in 3rd trimester placental samples asso...
ORGANISM(S): Homo sapiens 
2014-01-15 | E-GEOD-49343 | biostudies-arrayexpress
TranscriptomicsDNA methylation in Early Onset Preeclamptic placentas
We investigated the DNA methylation and gene expression of 20 chorionic villi samples from early onset preeclampsia placentas to 20 gestational age matched controls. From this we were able to see a widespread disregulation in DNA methylation across a subset of genes in the genome. This may help to e...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-44667 | biostudies-arrayexpress
TranscriptomicsGene expression in Early-Onset Preeclampsia Placentas and Controls
We investigated the DNA methylation and gene expression of 20 chorionic villi samples from early onset preeclampsia placentas to 20 gestational age matched controls. From this we were able to see a widespread disregulation in DNA methylation across a subset of genes in the genome. This may help to e...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-44711 | biostudies-arrayexpress
GenomicsExamination of four human tissue samples by MethylC-seq
As genome-scale DNA methylation sequencing technologies have improved it has become apparent that tissue-specific methylation can occur not only at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated ...
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-39775 | biostudies-arrayexpress
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