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TranscriptomicsDual knockdown of Esrrb and Sox2 in mouse embryonic stem cells
Esrrb, Sox2 or Esrrb and Sox2 were knocked down in mouse ES cells using shRNA plasmid pSUPER.puro containing shRNAs from the publications Feng et al., 2009 and Rodda et al., 2005. Knockdown was transfected into mouse ES cells using lipofectamine and then cells were selected for knockdown using purom...
ORGANISM(S): Mus musculus 
2012-11-22 | E-GEOD-34170 | biostudies-arrayexpress
TranscriptomicsBET Protein Inhibition shows Efficacy Against JAK2V617F-Driven Neoplasms
Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of MLL-fusion protein driven leukemias. Here, we report that I-BET151, a highly specific BET family bromodomain inhibitor...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-MTAB-1817 | biostudies-arrayexpress
UnknownAge- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.
Not available
S-EPMC5019754 | biostudies-literature
ProteomicsTWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression
Cholangiocarcinoma is a cancer of the hepatic bile ducts that is typically detected at a stage too advanced for resection. Additionally, chemotherapy is of limited efficacy, hence, novel therapeutic approaches are urgently required, including targeting of the cancer stroma. A macrophage-derived sign...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084273 | MassIVE
TranscriptomicsGSK8814: a chemical probe fort he ATAD2 bromodomain
Differential gene expression analysis of LNCaP cells treated with GSK8814 and GSK8815 Total RNA obtained from cells treated with GSK8814 and GSK8815 for 24 hours
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78868 | biostudies-arrayexpress
UnknownEvaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.
Not available
S-EPMC4863474 | biostudies-literature
UnknownProtein-altering germline mutations implicate novel genes related to lung cancer development.
Not available
S-EPMC7214407 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
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