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Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of MLL-fusion protein driven leukemias. Here, we report that I-BET151, a highly specific BET family bromodomain inhibitor...
ORGANISM(S): Homo sapiens 
Sox2 is a master transcriptional regulator of embryonic development. Having found that Sox2 interacts with RNA-binding proteins, we designed an experiment to discover RNAs associated with Sox2 and other pluripotency factors. Briefly, we used RNA immunoprecipitation followed by high-throughput sequen...
ORGANISM(S): Mus musculus 
Transcriptome profiling of mouse embryonic stem cells following antisense knockdown of the non-coding RNA 7SK.
ORGANISM(S): Mus musculus 
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary brea...
Segmented (HMM) copy number aberrations (CNA); discovery set
Segmented (CBS) copy number variants (CNV); discovery set
Normalized expression data; discovery set
Illumina HT 12 IDAT files
Segmented (CBS) copy number aberrations (CNA); validation set
Segmented (CBS) copy number aberrations (CNA); discovery set
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