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TranscriptomicsRocaglamide A converts RNA helicase eIF4A into a sequence-specific translational repressor
Rocaglamide A (RocA) typifies a novel class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), the prototypical DEAD-box RNA helicase, and its mRNA selectivity is proposed to ref...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-70211 | biostudies-arrayexpress
TranscriptomicsRocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its mRNA selectivity is proposed to reflect highl...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-79392 | biostudies-arrayexpress
UnknownSingle Amino Acid Replacements in RocA Disrupt Protein-Protein Interactions To Alter the Molecular Pathogenesis of Group A Streptococcus.
Not available
S-EPMC7573446 | biostudies-literature
UnknownIdentification of rocA, a positive regulator of covR expression in the group A streptococcus.
Not available
S-EPMC154078 | biostudies-literature
UnknownThe group A Streptococcus accessory protein RocA: regulatory activity, interacting partners and influence on disease potential.
Not available
S-EPMC7028121 | biostudies-literature
UnknownMyogenic Precursors from iPS Cells for Skeletal Muscle Cell Replacement Therapy.
Not available
S-EPMC4470123 | biostudies-literature
UnknownRocA Is an Accessory Protein to the Virulence-Regulating CovRS Two-Component System in Group A Streptococcus.
Not available
S-EPMC5649027 | biostudies-literature
UnknownThe Proteome of Pig Spermatozoa Is Remodeled During Ejaculation.
Not available
S-EPMC6317480 | biostudies-literature
UnknownNovel PiuC, PirA, and PiuA mutations leading to <i>in vivo</i> cefiderocol resistance progression in IMP-16- and KPC-2-producing <i>Pseudomonas aeruginosa</i> from a leukemic patient.
Not available
S-EPMC11878004 | biostudies-literature
UnknownNrdI essentiality for class Ib ribonucleotide reduction in Streptococcus pyogenes.
Not available
S-EPMC2447006 | biostudies-literature
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