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GenomicsRocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
PRJNA596665 | ENA
TranscriptomicsRocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies. As a result, this family of compounds has been significantly expanded through the development of efficient synthetic...
ORGANISM(S): Homo sapiens 
2020-03-02 | GSE142338 | GEO
UnknownAmidino-Rocaglates: A Potent Class of eIF4A Inhibitors.
Not available
S-EPMC6874763 | biostudies-literature
UnknownRocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F.
Not available
S-EPMC7077502 | biostudies-literature
UnknownExploring the targeting spectrum of rocaglates among eIF4A homologs.
Not available
S-EPMC10187672 | biostudies-literature
UnknownAmidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis.
Not available
S-EPMC11434215 | biostudies-literature
UnknownStructural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1.
Not available
S-EPMC11840593 | biostudies-literature
UnknownTreatment resistance analysis reveals GLUT-1-mediated glucose uptake as a major target of synthetic rocaglates in cancer cells.
Not available
S-EPMC8495295 | biostudies-literature
UnknownChanneling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis.
Not available
S-EPMC8333345 | biostudies-literature
UnknownRocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity.
Not available
S-EPMC8950828 | biostudies-literature
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