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ProteomicsProteomics and lipidomics analysis reveal lipid and calcium signalling as dysregulated pathways associated to sacsin loss
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare uncurable neurodegenerative disease caused by mutation in SACS gene coding for sacsin, a large protein involved in protein homeostasis, mitochondrial function, cytoskeleton dynamics, autophagy, cell adhesion and vesicle tra...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD049199 | Pride
Autosomal recessive spastic ataxia of charlevoix-saguenay Arsacs Proteomics Lc-ms/ms 
TranscriptomicsRISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells (miRNA-Seq)
We performed an integrated analysis of RNA and proteins at the transition between naïve ES cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators were specifically released from translational inhibition mediated by RNA-Induced Silencing Complex (RISC)...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-79654 | biostudies-arrayexpress
TranscriptomicsRISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells (TRAP)
We performed an integrated analysis of RNA and proteins at the transition between naïve ES cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators were specifically released from translational inhibition mediated by RNA-Induced Silencing Complex (RISC)...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-79653 | biostudies-arrayexpress
TranscriptomicsRISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells (RNAi)
We performed an integrated analysis of RNA and proteins at the transition between naïve ES cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators were specifically released from translational inhibition mediated by RNA-Induced Silencing Complex (RISC)...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-79652 | biostudies-arrayexpress
TranscriptomicsRISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells (RIP)
We performed an integrated analysis of RNA and proteins at the transition between naïve ES cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators were specifically released from translational inhibition mediated by RNA-Induced Silencing Complex (RISC)...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-79649 | biostudies-arrayexpress
TranscriptomicsRISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells (RNA)
We performed an integrated analysis of RNA and proteins at the transition between naïve ES cells and cells primed to differentiate. During this transition, mRNAs coding for chromatin regulators were specifically released from translational inhibition mediated by RNA-Induced Silencing Complex (RISC)...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-79650 | biostudies-arrayexpress
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