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MetabolomicsThe enduring effects of early-life HFHS exposure and microbiota-targeted interventions on blood metabolome in adult female and male mice

Blood metabolomics of 12-week-old female and male C57BL/6J mice that were exposed to either a control or an unhealthy high-fat/high-sugar (HFHS) diet during early-life, or early-life HFHS diet supplemented with a microbiota-targeted intervention (either a prebiotic combination (fructo-oligosaccha...

2026-01-27 | MTBLS12714 | MetaboLights
TranscriptomicsA gp130-induced Src/Yes-YAP Cascade Links Inflammation to Regeneration in the Mammalian Intestine
gp130Act cDNA was PCR-amplified and inserted into a plasmid containing the 12.4-kb Villin promoter. The 15.7-kb expression cassette was excised by PmeI digestion, purified, and injected into fertilized C57BL/6 oocytes to obtain founder mice, two of which transmitted the gp130Act transgene. Small int...
ORGANISM(S): Mus musculus 
2015-02-21 | E-MTAB-2400 | biostudies-arrayexpress
GenomicsTight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [ChIP-Seq]
A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through ...
ORGANISM(S): Homo sapiens 
2013-07-21 | E-GEOD-45852 | biostudies-arrayexpress
TranscriptomicsMeta-transcriptomic analysis of the response of river biofilms to pharmaceutical products using anonymous DNA microarray
Low concentrations of pharmaceutical compounds were shown to induce transcriptional responses in isolated microorganisms, which could have consequences on ecosystem dynamics. In order to test if these transcriptional responses could also be observed in complex river microbial communities, biofilm re...
ORGANISM(S): environmental samples 
2010-07-06 | E-GEOD-20501 | biostudies-arrayexpress
TranscriptomicsBlood Gene Expression Signatures Predict Invasive Candidiasis
Focusing on host response to infection, we utilized a murine model to develop a  blood gene expression signature that accurately classified mice with candidemia and distinguished candidemia from S. aureus bacteremia.  Validation of the signature was achieved in an independent cohort of mice. BALB/...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-20524 | biostudies-arrayexpress
TranscriptomicsEmpirical Annotation of the Daphnia pulex genome; Experiment B
Experiments conducted on this tiling array are used to (1) validate the frozen gene sets of the current genome annotation, (2) improve the predicted gene structures by empirically determining UTRs and intron-exon boundaries, identifying missing upstream, internal, and downstream exons and alternativ...
ORGANISM(S): Daphnia pulex 
2011-02-01 | E-GEOD-25852 | biostudies-arrayexpress
TranscriptomicsEmpirical Annotation of the Daphnia pulex genome; Experiment A
Experiments conducted on this tiling array are used to (1) validate the frozen gene sets of the current genome annotation, (2) improve the predicted gene structures by empirically determining UTRs and intron-exon boundaries, identifying missing upstream, internal, and downstream exons and alternativ...
ORGANISM(S): Daphnia pulex 
2011-02-01 | E-GEOD-25855 | biostudies-arrayexpress
TranscriptomicsEmpirical Annotation of the Daphnia pulex genome; Experiment C
Experiments conducted on this tiling array are used to (1) validate the frozen gene sets of the current genome annotation, (2) improve the predicted gene structures by empirically determining UTRs and intron-exon boundaries, identifying missing upstream, internal, and downstream exons and alternativ...
ORGANISM(S): Daphnia pulex 
2011-02-01 | E-GEOD-25856 | biostudies-arrayexpress
ProteomicsProteomic Analysis and Validation of the RGS14 Signaling Interactome in the Mouse Brain
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein with an unusual domain structure that allows it to integrate G protein and mitogen-activated protein kinase (MAPK) signaling pathways. RGS14 mRNA and protein are enriched in brain tissue of rodents and primates. In the adul...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-25 | PXD008461 | Pride
Rgs14 Immunoprecipitation Neuroproteomics Interactome 
TranscriptomicsTranscription profiling of human Burkitts lymphoma cells (L3055) treated with low and high concentrations of CD154
Activated B cells reacting to small amounts of CD40 ligand (CD154) maintain homeostasis by suppressing default apoptosis. Additional outcomes, particularly differentiation, demand higher CD40 occupancy. Here we compared changes in the transcriptome of pleiotropically competent, early-passage L3055 B...
ORGANISM(S): Homo sapiens 
2007-05-31 | E-MEXP-1113 | biostudies-arrayexpress
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