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TranscriptomicsThe orphan nuclear hormone receptor ERR-beta controls rod photoreceptor survival.
Mutation of rod photoreceptor-enriched transcription factors is a major cause of inherited blindness. We identified the orphan nuclear hormone receptor ERRβ as selectively expressed in rod photoreceptors. Overexpression of ERRβ induces expression of rod-specific genes in retinas of both wildtype ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21944 | biostudies-arrayexpress
TranscriptomicsTranscriptome dynamics of developing photoreceptors in 3-D retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks
To define molecular mechanisms underlying rod and cone differentiation, we generated H9 human embryonic stem cell line carrying a GFP reporter that is controlled by the promoter of cone-rod homeobox (CRX) gene, the first known marker of post-mitotic photoreceptor precursors. CRXp-GFP reporter in H9 ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-67645 | biostudies-arrayexpress
ProteomicsMouse rod photoreceptor Prkaa2 knockout phosphoproteomics
Mouse rod photoreceptors isolated from retinas of Prkaa2 rod photoreceptor specific knockout mice were processed for phosphoproteomics to elucidate downstream kinase targets. Prkaa2 is an isoform of the catalytic subunit of AMP-activated protein kinase (AMPK), an essential nutrient-sensing enzyme re...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD045669 | Pride
Mouse  rod photoreceptor  prkaa2  ampk  phosphoproteomics 
TranscriptomicsDistinct signature of altered homeostasis in aging rod photoreceptors: Implications for retinal diseases
To better understand the mechanistic basis of aging and its relationship with retinal degeneration, we examined gene expression changes in aging rod photoreceptors. Rod photoreceptor cell death is a feature of normal retinal aging and is accelerated in many retinal degenerative diseases, including A...
ORGANISM(S): Mus musculus 
2010-06-14 | E-GEOD-22317 | biostudies-arrayexpress
ProteomicsMouse rod photoreceptor Prkaa1 knockout phosphoproteomics
Mouse rod photoreceptor specific Prkaa1 knockouts were isolated from retinas and processed for phosphoproteomics to elucidate downstream kinase targets. Prkaa1 is one of the isoforms for the catalytic subunit of AMP-activated protein kinase (AMPK), an essential nutrient sensing enzyme responsible fo...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD045667 | Pride
Mouse Ampk Rod photoreceptors Prkaa1 Phosphoproteomics 
Transcriptomicssmall RNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biologica...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55376 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates
We report RNAseq analysis of the transcriptome of retinas from mature rod-specific Dicer1 cKO mice and control littermates lacking Cre expression in order to better understand changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biologica...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-55377 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in wildtype and Notch1 mutant retinal cells by single cell profiling
Loss of Notch1 in retinal progenitor cells (RPCs) during postnatal retinal development results in the overproduction of rod photoreceptors at the expense of interneurons and glia. To examine the molecular underpinnings of this observation, microarray analysis of singla retinal cells from wildtype (W...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-35682 | biostudies-arrayexpress
GenomicsEpigenetic and transcriptional changes in aging mouse rod photoreceptors [WGBS]
Epigenetic and transcriptional changes in aging mouse rod photoreceptors [WGBS]
PRJNA556668 | ENA
ModelsTikidji-Hamburyan2018 - Rod phototransduction under strong illumination
Tikidji-Hamburyan2018 - Rod phototransduction under strong illumination This model is described in the article: Rods progressively escape saturation to drive visual responses in daylight conditions. Tikidji-Hamburyan A, Reinhard K, Storchi R, Dietter J, Seitter H, Davis KE, ...
MODEL1710030000 | BioModels
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