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ProteomicsEffect of the Src inhibitor peptide TAT-Cx43266-283 in lung cancer brain metastasis models.
Background: TAT-Cx43266-283 is a novel inhibitor of Src, which has shown important antitumor effects in preclinical models of glioblastoma. Because Src plays a pivotal role in several tumors, including lung cancer and brain metastasis, in this study we investigated the effect of TAT-Cx43266-283 in l...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-02 | PXD058276 | Pride
Cancer stem cells Metastasis Src Tumor Phosphoproteomics 
ProteomicsKinase Substrate Enrichment Analysis Provides Insights into the Heterogeneity of Signaling Pathway Activation in Leukemia Cells
Experiments were performed in AML (Acute Myeloid Leukemia) cell lines and in primary cells coming from patients with AML and healthy donors. The AML cell lines P31/Fuj and Kasumi-1 were treated with vehicle (DMSO), 100 nM or 1000 nM of the PI3K/mTOR inhibitor AZ123 or the mTOR inhibitor Ku0063794 f...
ORGANISM(S): Homo sapiens (Human) 
2013-04-09 | PXD000185 | Pride
Tio2 phosphoenrichment Label free quantification Aml primary cells Pi3k/mtor inhibitors 
ProteomicsPhosphoproteomics data classify haematological cancer cell lines according to tumour type and sensitivity to kinase inhibitors
Acute myeloid leukemia, lymphoma and multiple myeloma cell lines were grown for 24h in RPMI medium and cells were harvested by centrifugation. Samples were digested with trypsin and subjected to phosphoenrichment using IMAC. Phosphopeptides were run in a LTQ-Orbitrap-XL. Peaks lists were generated ...
ORGANISM(S): Homo sapiens (Human) 
2013-04-26 | PXD000217 | Pride
Kinase inhibitor Drug sensitivity Imac Phosphoproteomics Hierarchical clustering analysis Blood malignancies Acute myeloid leukemia 
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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