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ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we demonstrate that dimeric IgA, but not the same antib...
ORGANISM(S): Homo Sapiens 
PXD044426 | panorama
UnknownDiscovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.
Not available
S-EPMC5458547 | biostudies-literature
UnknownAn Exploratory Survey on the Care for Ataxic Patients in the American Continents and the Caribbean.
Not available
S-EPMC10461795 | biostudies-literature
UnknownChromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma.
Not available
S-EPMC7545147 | biostudies-literature
UnknownWhole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.
Not available
S-EPMC4381520 | biostudies-literature
GenomicsGenome Wide Association for Asthma and Lung Function

The SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic (STAMPEED) asthma project includes subjects with asthma and controls from the Chicago Asthma Genetics Study (CAG), NHLBI multicenter Severe Asthma Research Program (SARP) and NHLBI Collaborative Studies ...

phs000355.v1.p1 | EGA
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
UnknownHigh-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial.
Not available
S-EPMC8828369 | biostudies-literature
UnknownProspective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients.
Not available
S-EPMC9095637 | biostudies-literature
UnknownDNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples.
Not available
S-EPMC12036262 | biostudies-literature
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