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ProteomicsInteractome screening of C9orf72 dipeptide repeats reveals sequestration and functional impairment of VCP by polyGA
Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translation to produce unnatural dipeptide rep...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD024120 | Pride
Proximity labeeling Proteomics Amyotrophic lateral sclerosis Als Valosin-containing protein Vcp Bioid Neurodegeneration Dipeptide repeats 
TranscriptomicsAlternative splicing in Mouse E18 brain
Total RNA was extracted from wild-type and FUS -/- mouse E18 brain samples using RNeasy kit, cDNA was synthesized using GeneChip WT cDNA Synthesis and Amplification kit (Affymetrix 900673) and hybridised to Affymetrix mouse high-resolution AltSplice microarrays.
ORGANISM(S): Mus musculus 
2013-07-30 | E-MTAB-1229 | biostudies-arrayexpress
TranscriptomicsAlternative splicing in human temporal cortex
We analysed changes in transcript levels and alternative splicing in the temporal cortex of individuals of different ages that were cognitively normal, affected by frontotemporal lobar degeneration (FTLD), or affected by Alzheimer's disease (AD). Our experiment's purpose is to provide new insights i...
ORGANISM(S): Homo sapiens 
2012-04-27 | E-MTAB-656 | biostudies-arrayexpress
TranscriptomicsTDP 43 Knockdown
RNA_BINDING, identify global RNA binding sites for TDP43 protein
ORGANISM(S): Homo sapiens 
2011-03-25 | E-MTAB-527 | biostudies-arrayexpress
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