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TranscriptomicsThe G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation
OGR1 is a pH sensing G protein-coupled receptor involved in intestinal homeostasis and inflammation. Up-regulation of genes, mediated by OGR1, in response to extracellular acidification were enriched for inflammation, immune response, actin cytoskeleton and cell adhesion pathways. Microarray profili...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-60295 | biostudies-arrayexpress
TranscriptomicsThe pH-sensing receptor OGR1 improves barrier function of CaCo-2 cells and inhibits migration in an acidic environment
OGR1 is a pH-sensing G-protein coupled receptor involved in intestinal homeostasis and inflammation Proton activation of OGR1 increases barrier function in Caco2 cells Microarray profiling was performed on OGR1 stable overexpressing Caco-2 cells during acidic pH shift
ORGANISM(S): Homo sapiens 
2015-08-13 | E-GEOD-60294 | biostudies-arrayexpress
ProteomicsCommensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
We identified certain members of the gut microbiota associated with a lower tumor burden in mouse models of colorectal cancer (CRC). Orally applied, a mix of four Clostridiales strains (CC4) prevented and even successfully treated CRC as a stand-alone therapy.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-06-15 | MSV000087624 | MassIVE
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