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ProteomicsA workflow towards the reproducible identification and quantitation of protein carbonylation sites in human plasma
Protein carbonylation has been consistently used as a marker of excessive oxidative stress and studied in the context of multiple human oxidative stress related diseases. The variety of carbonyl post-translational modifications (PTMs) and their low abundance on easily accessible diagnostic tissues (...
ORGANISM(S): Homo sapiens (Human) 
2021-03-02 | PXD023738 | Pride
Protein carbonylation Lc-twims-ms/ms Aldehyde reactive probe (arp) Human plasma Biotin-avidin affinity 
ProteomicsPeptide centric detection of cross-linked peptides using PASEF, MeroX, and Skyline
Cross-linking mass spectrometry (XL-MS) has evolved into a pivotal technique for probing protein interactions, with recent ad-vancements significantly enhancing its analytical potential. This technical note presents advancements in cross-linking mass spec-trometry (XL-MS) through the implementation ...
ORGANISM(S): Bos Taurus 
PXD047307 | panorama
ProteomicsImproving peptide fragment ion detection using travelling wave ion mobility spectrometry with signal enhancement MSE (seMSE)
Recently, a solution to inherent poor ion beam sampling of time-of-flight (TOF) mass analyzers was proposed by restricting detection to ions expected at specific arrival times after being separated in a travelling wave ion mobility spectrometry (TWIMS) cell. Here, we show that this approach can be a...
ORGANISM(S): Oryctolagus Cuniculus Escherichia Coli Bos Taurus Saccharomyces Cerevisiae 
2022-08-01 | PXD030431 | panorama
ProteomicsScreening of protein carbonylation sites in human serum by ion mobility mass spectrometry
Excessive oxidative stress, which is associated with several diseases, can trigger oxidative protein modifications, including protein carbonylation, which refers to the oxidative formation of aldehyde or keto groups in proteins. The structural diversity of these non-enzymatic reactive carbonyl group...
ORGANISM(S): Homo Sapiens 
PXD058666 | panorama
ProteomicsMolecular details of ligand binding to the intrinsically disordered N terminus of the neuropeptide Y receptor
Neuropeptide Y (NPY) receptors comprise a family of rhodopsin-like G-protein coupled receptors (GPCRs) that participate in controlling food intake, memory retention, and circadian rhythm, making them highly attractive drug targets. However, the multiligand nature of NPY receptors, such as the NPY re...
ORGANISM(S): Homo Sapiens Escherichia Coli Sus Scrofa 
2026-03-24 | PXD051865 | panorama
ProteomicsAnalysis of N-Glycosylation for SARS-CoV-2 expressed receptor-binding domain VOCs and membrane protein with LC-MS.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect human cells by first attaching to the ACE-2 receptor via its receptor-binding domain (RBD) in the spike protein. We investigated the influence of N-glycosylation sites of the RBD and the membrane (M) protein on IgG antibody bind...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
PXD048930 | panorama
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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