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TranscriptomicsTranscription profiling by array of HC11 mammary epithelial cell strains stably expressing different variants of the transcriptional regulator megakaryoblastic leukemia-1 (Mkl1)
We have previously shown that HC11 mammary epithelial cells react strongly to the overexpression of megakaryoblastic leukemia-1 (Mkl1) with induction of tenascin-C expression. The present study was designed to find genes co-regulated with tenascin-C by Mkl1 in a SAP domain-dependent manner and witho...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-44907 | biostudies-arrayexpress
TranscriptomicsPIK3CA(H1047R)-evoked breast tumorigenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-59874 | biostudies-arrayexpress
TranscriptomicsExpression data from HEK293 Flp-In cells constitutivly expressing FLAG-HA-tagged TRIM71 and that of the parental cell line
We identify mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability. In this data set we compare the expression profile of human HEK293 Flp-In cells stably expressing TRIM71 to that of the parental cells, not expressing TRIM71 protein. Experiment was performed in ...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-37713 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse embryonic stem cells upon TRIM71 KD and parental ctrl cells
We identify mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability. In this data set we compare the expression profile of mouse ES upon Trim71 KD versus that of the parental cells. Experiment was performed in triplicate.
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-37712 | biostudies-arrayexpress
TranscriptomicsMammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-37714 | biostudies-arrayexpress
TranscriptomicsMiRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58501 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of preneoplastic Lgr5-creERT2/PIK3CAH1047R mammary subsets
This study examined the effect of mutant PIK3CAH1047R expression in mammary subsets of preneoplastic mammary glands from Lgr5-creERT2/PIK3CA H1047R mice Mammary cell subpopulations were isolated from Lgr5-creERT2/PIK3CA H1047R and Lgr5-creERT2 control animals 4 weeks after activation of PIK3CA H1047...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-59870 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of preneoplastic K8-creERT2/PIK3CAH1047R mammary subsets
This study examined the effect of mutant PIK3CAH1047R expression in mammary subsets of preneoplastic mammary glands from K8-creERT2/PIK3CA H1047R mice Mammary cell subpopulations were isolated from K8-creERT2/PIK3CAH1047R and K8-creERT2 control animals 4 weeks after activation of PIK3CA H1047R trans...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-65411 | biostudies-arrayexpress
TranscriptomicsExpression data of wild type and C-DGCR8 KO cones at different timepoints [RNA-seq]
We have analyzed gene expression in cone photoreceptors isolated from wild type and C-DGCR8 (DiGeorge Syndrome Critical Region Gene 8) KO mice at five different time points to get a mechanistic inside into the altered molecular pathways after microRNAs depletion. Cones were isolated by FACS from wil...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-58498 | biostudies-arrayexpress
TranscriptomicsGenomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells (ChIP-chip)
Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional plasticity and potential. Here we report the dynami...
ORGANISM(S): Mus musculus 
2011-06-21 | E-GEOD-27724 | biostudies-arrayexpress
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