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GenomicsNatural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress
TranscriptomicsGene expression in liver tissues derived from wild-type and Siglec-E-deficient mice at 55 weeks of age
We show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS m...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-64760 | biostudies-arrayexpress
GenomicsControl of VEGF-A trancriptional programs by pausing and genomic compartmentalization
Vascular endothelial growth factor A (VEGF-A) is a master regulator of vascular development and function. Consequently, VEGF-A regulated gene expression programs have been under heavy research. In this study we study the transcriptional regulation of VEGF-A-responsive genes in primary aortic endothe...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-52642 | biostudies-arrayexpress
GenomicsRemodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress
UnknownControl of VEGF-A transcriptional programs by pausing and genomic compartmentalization.
Not available
S-EPMC4227755 | biostudies-literature
UnknownSiglec receptors impact mammalian lifespan by modulating oxidative stress.
Not available
S-EPMC4384638 | biostudies-literature
TranscriptomicsEnvironment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities
Macrophages reside in essentially all tissues of the body and play key roles in innate and adaptive immune responses. Distinct populations of tissue macrophages also acquire context-specific functions that are important for normal tissue homeostasis. To investigate mechanisms responsible for tissue-...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-62826 | biostudies-arrayexpress
UnknownOxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Not available
S-EPMC5997752 | biostudies-literature
UnknownBiological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
Not available
S-EPMC8651638 | biostudies-literature
UnknownAssociation of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease.
Not available
S-EPMC3861448 | biostudies-literature
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